Four-dimensional measurement of intrafractional respiratory motion of pancreatic tumors using a 256 multi-slice CT scanner
Four-dimensional measurement of intrafractional respiratory motion of pancreatic tumors using a 256 multi-slice CT scanner
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DOI：
10.1016/j.radonc.2008.12.015
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发表时间：
2009-08-01
影响因子：
5.7
通讯作者：
Kamada, Tadashi
中科院分区：
文献类型：
--
作者：
Mori, Shinichiro;Hara, Ryusuke;Kamada, Tadashi
目的：利用容积电影CT图像定量评价胰腺及胰腺肿瘤在呼吸运动中的运动情况。材料与方法：对6例胰腺肿瘤患者在自由呼吸条件下，采用256多层螺旋CT扫描机进行电影扫描。肿瘤大体体积(GTV)和胰腺在CT数据集上由放射肿瘤学家手动绘制轮廓。计算GTV和胰腺的分数内呼吸运动，并比较呼吸非门控和门控呼吸时的结果，即呼气周围30%的占空比。结果：呼吸诱导的器官运动主要发生在前腹侧，而不是后侧。GTV平均移位(非门控/门控位相)左右方向为0.7 mm/0.2 mm，前位移位为2.5 mm/0.9 mm，后位移位为0.1 mm/0 mm，下位移位为8.9 mm/2.6 mm。胰腺质量中心相对于呼气峰的平均移位主要在下方，非门控时为9.6 mm，门控时为2.3 mm。结论：定量分析肿瘤和胰腺移位可以准确确定边缘，为所有胰腺肿瘤放射治疗方案的制定提供有价值的信息。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。放射治疗与肿瘤学92(2009)231-237
Purpose: To quantify pancreas and pancreatic tumor movement due to respiratory motion using volumetric cine CT images.Materials and methods: Six patients with pancreatic tumors were scanned in cine mode with a 256 multi-slice CT scanner under free breathing conditions. Gross tumor volume (GTV) and pancreas were manually contoured on the CT data set by a radiation oncologist. Intrafractional respiratory movement of the GTV and pancreas was calculated, and the results were compared between the respiratory ungated and gated phases, which is a 30% duty cycle around exhalation.Results: Respiratory-induced organ motion was observed mainly in the anterior abdominal side than the posterior side. Average GTV displacement (ungated/gated phases) was 0.7 mm/0.2 mm in both the left and right directions, and 2.5 mm/0.9 mm in the anterior, 0.1 mm/0 mm in the posterior, and 8.9 mm/2.6 mm in the inferior directions. Average pancreas center of mass displacement relative to that at peak exhalation was mainly in the inferior direction, at 9.6 mm in the ungated phase and 2.3 mm in the gated phase.Conclusions: By allowing accurate determination of the margin, quantitative analysis of tumor and pancreas displacement provides useful information in treatment planning in all radiation approaches for pancreatic tumors. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 92 (2009) 231-237