Standardised FDG uptake: A prognostic factor for inoperable non-small cell lung cancer
Standardised FDG uptake: A prognostic factor for inoperable non-small cell lung cancer
复制标题
DOI：
10.1016/j.ejca.2005.03.026
复制
发表时间：
2005-07-01
影响因子：
8.4
通讯作者：
Lebesque, JV
中科院分区：
文献类型：
--
作者：
Borst, GR;Belderbos, JSA;Lebesque, JV
本研究的目的是探讨[F-18]氟脱氧葡萄糖正电子发射断层扫描（FDG PET）获得的标准化摄取值（SUV）与接受高剂量放疗的不可手术非小细胞肺癌（NSCLC）患者的治疗反应/生存率之间的关系。51名患者被纳入记录阶段，性能，体重减轻，肿瘤体积，组织学，淋巴结受累，SUV，和交付的辐射剂量。原发肿瘤内的最大SUV（SUVmax）是预测治疗反应的敏感和特异性因素。除SUVmax外，分期和体能也是治疗反应的独立预测因素。在多变量疾病特异性生存（DSS）分析中，SUVmax（P = 0.01），体力状态（P = 0.008）和阶段（P = 0.04）是预后因素。对于总生存期（OS），SUVmax（P = 0.001）和性能（P = 0.06）是重要的预后因素。SUVmax是不可手术NSCLC患者生存的重要预后因素，也是治疗反应的预测因素。虽然患者数量较少，治疗不均匀，FDG SUV的使用可能有限制，我们仍然得出结论，FDG SUV可能是选择不同治疗策略的患者的良好指标。(c)2005爱思唯尔有限公司保留所有权利。
The aim of this study was to investigate the relationship between standardised uptake value (SUV) obtained from [F-18]fluorodeoxyglucose positron emission tomography (FDG PET) and treatment response/survival of inoperable non-small cell lung cancer (NSCLC) patients treated with high dose radiotherapy. Fifty-one patients were included recording stage, performance, weight loss, tumour volume, histology, lymph node involvement, SUV, and delivered radiation dose. The maximum SUV (SUVmax) within the primary tumour was a sensitive and specific factor for predicting treatment response. Apart from SUVmax, stage and performance were also independent predictive factors for treatment response. In a multivariate disease-specific survival (DSS) analysis, SUVmax (P = 0.01), performance status (P = 0.008) and stage (P = 0.04) were prognostic factors. For overall survival (OS), SUVmax (P = 0.001) and performance (P = 0.06) were important prognostic factors. SUVmax was an important prognostic factor for survival of inoperable NSCLC patients and a predictive factor for treatment response. Although the number of patients was small, the treatment was not homogeneous and the use of FDG SUV may have had constraints, we still conclude that the FDG SUV is potentially a good indicator for selecting patients for different treatment strategies. (c) 2005 Elsevier Ltd. All rights reserved.