Personalized Intrinsic Network Topography Mapping and Functional Connectivity Deficits in Autism Spectrum Disorder
Personalized Intrinsic Network Topography Mapping and Functional Connectivity Deficits in Autism Spectrum Disorder
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DOI：
10.1016/j.biopsych.2018.02.1174
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发表时间：
2018-08-15
影响因子：
10.6
通讯作者：
Voineskos, Aristotle N.
中科院分区：
文献类型：
--
作者：
Dickie, Erin W.;Ameis, Stephanie H.;Voineskos, Aristotle N.
背景技术背景：最近的进展，在技术上使用功能磁共振成像数据表明，个别特定的变化，在健康个体的大脑结构。据我们所知，在复杂的大脑disorders.METHODS个别特定的变化的影响，我们开发了一种新的方法（个性化的内在网络拓扑，PINT）本地化个别特定的静息状态网络使用传统的静息状态功能磁共振成像扫描。使用自闭症谱系障碍参与者的横断面数据我们在15个地点对ASD（n = 393）和典型发展中（TD）对照参与者（n = 496）进行了测试：1）诊断和年龄对内在网络位置变异性的影响，以及2）在PINT应用后，ASD患者与TD患者相比，先前发现的功能连接差异是否仍然存在。我们发现，与TD个体相比，ASD个体内的静息状态网络的空间位置具有更大的变异性。对于TD的人，变异性从童年到成年减少，并在晚年增加，遵循U形模式，这在ASD患者中不存在。组之间的内在连接的比较显示，PINT的应用程序减少了在ASD的hypoconnected区域的数量。结论：我们的研究结果提供了一个新的框架，用于测量改变大脑功能的神经发育障碍，可能有影响的跟踪发展过程中，表型异质性，并最终治疗反应。我们强调在复杂的大脑疾病的研究中考虑个体差异的重要性。
BACKGROUND: Recent advances in techniques using functional magnetic resonance imaging data demonstrate individually specific variation in brain architecture in healthy individuals. To our knowledge, the effects of individually specific variation in complex brain disorders have not been previously reported.METHODS: We developed a novel approach (Personalized Intrinsic Network Topography, PINT) for localizing individually specific resting-state networks using conventional resting-state functional magnetic resonance imaging scans. Using cross-sectional data from participants with autism spectrum disorder (ASD; n = 393) and typically developing (TD) control participants (n = 496) across 15 sites, we tested: 1) effect of diagnosis and age on the variability of intrinsic network locations and 2) whether prior findings of functional connectivity differences in persons with ASD compared with TD persons remain after PINT application.RESULTS: We found greater variability in the spatial locations of resting-state networks within individuals with ASD compared with those in TD individuals. For TD persons, variability decreased from childhood into adulthood and increased in late life, following a U-shaped pattern that was not present in those with ASD. Comparison of intrinsic connectivity between groups revealed that the application of PINT decreased the number of hypoconnected regions in ASD.CONCLUSIONS: Our results provide a new framework for measuring altered brain functioning in neurodevelopmental disorders that may have implications for tracking developmental course, phenotypic heterogeneity, and ultimately treatment response. We underscore the importance of accounting for individual variation in the study of complex brain disorders.