Group-Based Trajectory Modeling in Clinical Research
Group-Based Trajectory Modeling in Clinical Research
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DOI：
10.1146/annurev.clinpsy.121208.131413
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Odgers, Candice L.
中科院分区：
文献类型：
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作者：
Nagin, Daniel S.;Odgers, Candice L.
基于群体的轨迹模型越来越多地被应用于临床研究，以绘制症状的发展历程并评估对临床干预的异质性。在这篇综述中，我们提供了基于群体的轨迹和生长混合模型的非技术概述，以及这些模型如何应用于临床研究的样本。我们讨论了与应用这两种类型的基于组的模型相关的挑战，并提出了一套初步的指导方针，供应用研究人员在报告模型结果时遵循。讨论了基于组的建模应用的未来方向，包括使用轨迹模型来促进在不可能随机分配到治疗条件时的因果推断。
Group-based trajectory models are increasingly being applied in clinical research to map the developmental course of symptoms and assess heterogeneity in response to clinical interventions. In this review, we provide a nontechnical overview of group-based trajectory and growth mixture modeling alongside a sampling of how these models have been applied in clinical research. We discuss the challenges associated with the application of both types of group-based models and propose a set of preliminary guidelines for applied researchers to follow when reporting model results. Future directions in group-based modeling applications are discussed, including the use of trajectory models to facilitate causal inference when random assignment to treatment condition is not possible.