Levels of maternal serum alpha-fetoprotein (AFP) in pregnant women and subsequent breast cancer risk.
Levels of maternal serum alpha-fetoprotein (AFP) in pregnant women and subsequent breast cancer risk.
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孕妇的母体血清甲胎蛋白 (AFP) 水平和随后的乳腺癌风险。
DOI：
10.1093/oxfordjournals.aje.a009691
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发表时间：
1998
影响因子：
5
通讯作者：
Calvin,JA
中科院分区：
文献类型：
--
作者：
Richardson,BE;Hulka,BS;Peck,JL;Hughes,CL;vandenBerg,BJ;Christianson,RE;Calvin,JA
怀孕期间母体血清甲胎蛋白（AFP）水平较高可能有助于降低随后患乳腺癌的风险。这一假设在一项巢式病例对照研究中得到了检验，该研究使用了加州大学伯克利分校儿童健康与发展研究 (CHDS) 小组在 1959 年至 1966 年间从一组孕妇中采集的冷冻血清。经组织学证实的乳腺癌病例是从加州癌症登记档案中确定的，涵盖其在 CHDS 中登记的日期，直至 1994 年。通过随机招募从 CHDS 队列中选择对照。使用放射免疫测定法和免疫酶法分析妊娠晚期母体血清 AFP 水平。在控制逻辑回归模型中的多个混杂因素后，作者发现妊娠期间母体血清 AFP（前四分位）水平高与乳腺癌风险之间存在负相关。高水平母体血清 AFP 的保护作用因首次足月妊娠年龄而异（20 岁或以下：比值比 (OR) = 0.43，95% 置信区间 (Cl) 0.28–0.65；年龄 21–23 岁：OR = 0.62，95% Cl 0.41–0.92）。 27 岁后，估计风险超过统一（OR = 1.67，95% Cl 1.14–2.45）。这些研究结果表明，首次足月妊娠早期对乳腺癌的预防作用可能是由于母体血清 AFP 水平较高。 27 岁后，母体血清 AFP 水平较高不再具有保护作用，反而可能增加风险。Am J Epidemiol1998； 148：719-27。
High maternal serum alpha-fetoprotein (AFP) levels during pregnancy may be instrumental in reducing the subsequent risk of breast cancer. This hypothesis was tested in a nested case-control study using stored frozen sera accrued between 1959 and 1966 by the University of California at Berkeley Child Health and Development Studies (CHDS) group from a cohort of pregnant women. Cases with histologically confirmed breast cancer were identified from California Cancer Registry files covering their date of enrollment in the CHDS until 1994. Controls were selected from the CHDS cohort by using randomized recruitment. Third-trimester maternal serum AFP levels were analyzed by using both a radioimmunoassay and an immunoen-zymatic method. After controlling for multiple confounders in logistic regression models, the authors found an inverse association between high levels of maternal serum AFP (top quartile) during the index pregnancy and the risk of breast cancer. The protective effect of high levels of maternal serum AFP varied by age at first full-term pregnancy (age 20 years or less: odds ratio (OR) = 0.43, 95% confidence interval (Cl) 0.28–0.65; age 21–23 years: OR = 0.62, 95% Cl 0.41–0.92). After age 27 years, the estimated risk exceeded unity (OR = 1.67, 95% Cl 1.14–2.45). These study findings suggest that some of the protection against breast cancer conferred by early first full-term pregnancy may result from high levels of maternal serum AFP. After age 27 years, a high maternal serum AFP level is not protective and may increase risk.Am J Epidemiol1998; 148:719–27.