On-Scalp Optically Pumped Magnetometers versus Cryogenic Magnetoencephalography for Diagnostic Evaluation of Epilepsy in School-aged Children
On-Scalp Optically Pumped Magnetometers versus Cryogenic Magnetoencephalography for Diagnostic Evaluation of Epilepsy in School-aged Children
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DOI：
10.1148/radiol.212453
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发表时间：
2022-08-01
期刊：
影响因子：
19.7
通讯作者：
Christiaens, Florence
中科院分区：
文献类型：
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作者：
Feys, Odile;Corvilain, Pierre;Christiaens, Florence
背景：脑磁图（MEG）是一种用于检测和定位局灶性癫痫样间歇放电（ied）的成熟方法。目前的MEG系统将数百个低温传感器装在一个刚性的、统一尺寸的头盔中，这导致了一些限制，特别是在儿童中。目的：确定基于光泵磁强计（OPMs）的头皮脑磁图是否缓解了低温脑磁图的主要局限性。材料与方法：在一所三级大学教学医院进行的这项前瞻性单中心研究中，参与者接受了低温（102个磁力计，204个平面梯度计）和头皮（32个OPMs）脑磁图检测。比较了两种检测和定位简易爆炸装置的方法。采用t检验比较IED幅值和信噪比。对基于opm和低温MEG数据进行分布式源建模。结果：5名儿童（中位年龄9.4岁[范围5-11岁]；4名女孩）患有自限性特发性局灶性癫痫（n = 3）或难治性局灶性癫痫（n = 2）。在所有五名儿童中都发现了简易爆炸装置，两种MEG装置的传感器地形相似。IED振幅分别为2.3(3.2 / 3.1)~ 4.6（3.2 / 0.7）倍
Background: Magnetoencephalography (MEG) is an established method used to detect and localize focal interictal epileptiform discharges (IEDs). Current MEG systems house hundreds of cryogenic sensors in a rigid, one-size-fits-all helmet, which results in several limitations, particularly in children.Purpose: To determine if on-scalp MEG based on optically pumped magnetometers (OPMs) alleviates the main limitations of cryogenic MEG.Materials and Methods: In this prospective single-center study conducted in a tertiary university teaching hospital, participants underwent cryogenic (102 magnetometers, 204 planar gradiometers) and on-scalp (32 OPMs) MEG. The two modalities for the detection and localization of IEDs were compared. The t test was used to compare IED amplitude and signal-to-noise ratio (SNR). Distributed source modeling was performed on OPM-based and cryogenic MEG data.Results: Five children (median age, 9.4 years [range, 5-11 years]; four girls) with self-limited idiopathic (n = 3) or refractory (n = 2) focal epilepsy were included. IEDs were identified in all five children with comparable sensor topographies for both MEG devices. IED amplitudes were 2.3 (7.2 of 3.1) to 4.6 (3.2 of 0.7) times higher (P