Moderate-intensity aerobic training improves glucose tolerance in aging independent of abdominal adiposity
Moderate-intensity aerobic training improves glucose tolerance in aging independent of abdominal adiposity
复制标题
DOI：
10.1111/j.1532-5415.1998.tb02722.x
复制
发表时间：
1998-07-01
影响因子：
6.3
通讯作者：
Nadel, ER
中科院分区：
文献类型：
--
作者：
DiPietro, L;Seeman, TE;Nadel, ER
目的：为了验证这一假设，即训练相关的改善葡萄糖和胰岛素对口服葡萄糖耐量试验（OGTT）的反应是独立的腹部肥胖的变化。设计：肥胖和对OGTT的反应之前和之后，4个月的随机对照有氧训练计划。地点：一个学术医疗机构。参与者：16名健康老年人。干预：训练组（T）（n = 9）和对照组（C）（n = 7）每周锻炼4次，每次60分钟。T在迷你蹦床上以最大心率的55%至65%进行锻炼（从分级跑步机测试确定）1个月，然后在75%持续3个月; C从事监督拉伸和瑜伽。测量：在基线和随访时，我们估计腹部脂肪（来自计算机断层扫描和人体测量），血糖，以及血清胰岛素对OGTT和空腹游离脂肪酸（FFA）浓度的反应。有氧训练导致T组的O-2峰值增加16%，FFA减少24%（P <0.05），但训练对腹部脂肪没有影响。T组葡萄糖反应曲线左移，葡萄糖曲线下面积增量减少25%（P
OBJECTIVE: To test the hypothesis that training-related improvements in glucose and insulin responses to an oral glucose tolerance test (OGTT) are independent of changes in abdominal adiposity.DESIGN: Adiposity and responses to an OGTT were measured before and after a 4-month randomized, controlled aerobic training program.SETTING: An academic medical institution.PARTICIPANTS: Sixteen healthy older (73 +/- 1 year) men and women.INTERVENTION: Both the training (T) (n = 9) and control (C) (n = 7) groups exercised 4 times a week for 60-minute sessions. T exercised on mini-trampolines at 55 to 65% of HRmax (determined from a graded treadmill test) for 1 month and then at 75% for 3 months; C engaged in supervised stretching and yoga.MEASUREMENTS: At baseline and follow-up, we estimated abdominal fat (from computed tomography and anthropometry), plasma glucose, and serum insulin responses to the OGTT and fasting concentrations of free fatty acids (FFA).RESULTS: Aerobic training resulted in a 16% increase in (V) over dot O-2 peak and a 24% decrease in FFA in the T group (P < .05), but training had no effect on abdominal fat. In the T group, the glucose response curve shifted to the left, and the incremental area under the glucose curve decreased by 25% (P