The assessment of regional gut transit times in healthy controls and patients with gastroparesis using wireless motility technology
The assessment of regional gut transit times in healthy controls and patients with gastroparesis using wireless motility technology
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DOI：
10.1111/j.1365-2036.2009.04162.x
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发表时间：
2010-01-15
影响因子：
7.6
通讯作者：
McCallum, R. W.
中科院分区：
文献类型：
--
作者：
Sarosiek, I.;Selover, K. H.;McCallum, R. W.
背景技术无线pH压力动力胶囊无线动力胶囊技术提供了一种评估局部胃肠通过时间的方法。目的分析胃轻瘫患者和健康对照者的多中心研究数据，并比较无线动力胶囊测量的健康对照者和胃轻瘫患者（GP）的局部胃肠通过时间。方法共66例健康对照者和34例GP患者。（15例糖尿病患者和19例特发性）与标准餐（255 kcal）一起吞咽无线动力胶囊。胃排空时间（GET），小肠通过时间（SBTT），结肠通过时间（CTT）和全肠通过时间（WGTT）计算使用无线动力胶囊。18%的胃轻瘫患者WGTT延迟。与健康对照组相比，糖尿病和特发性胃轻瘫患者的WGTT显著减慢（P < 0.0001），GET也显著减慢。糖尿病胃轻瘫患者另外有显着较慢的CTT比健康对照组（P = 0.0054）。结论除了评估胃排空，区域通过时间可以测量使用无线动力胶囊。胃轻瘫患者CTT的延长表明GP中存在胃以外的运动障碍，并且其可能有助于症状表现。Aliment Pharmacol Ther 31，313-322。
P>BackgroundWireless pH and pressure motility capsule (wireless motility capsule) technology provides a method to assess regional gastrointestinal transit times.AimsTo analyse data from a multi-centre study of gastroparetic patients and healthy controls and to compare regional transit times measured by wireless motility capsule in healthy controls and gastroparetics (GP).MethodsA total of 66 healthy controls and 34 patients with GP (15 diabetic and 19 idiopathic) swallowed wireless motility capsule together with standardized meal (255 kcal). Gastric emptying time (GET), small bowel transit time (SBTT), colon transit time (CTT) and whole gut transit time (WGTT) were calculated using the wireless motility capsule.ResultsGastric emptying time, CTT and WGTT but not SBTT were significantly longer in GP than in controls. Eighteen percent of gastroparetic patients had delayed WGTT. Both diabetic and idiopathic aetiologies of gastroparetics had significantly slower WGTT (P < 0.0001) in addition to significantly slower GET than healthy controls. Diabetic gastroparetics additionally had significantly slower CTT than healthy controls (P = 0.0054).ConclusionsIn addition to assessing gastric emptying, regional transit times can be measured using wireless motility capsule. The prolongation of CTT in gastroparetic patients indicates that dysmotility beyond the stomach in GP is present, and it could be contributing to symptom presentation.Aliment Pharmacol Ther 31, 313-322.