A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications
A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications
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人细胞色素 P450 3A4 的高选择性探针：异构体选择性、动力学表征及其应用。
DOI：
10.1039/c3cc45250f
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Yang, Ling
中科院分区：
文献类型：
--
作者：
Ge, Guang-Bo;Ning, Jing;Yang, Ling
蟾蜍灵5 β-羟基化被发现是细胞色素P450 3A 4（CYP 3A 4）的异构体特异性生物转化探针底物。该探针反应具有良好的特性，可用于测定不同酶源的CYP 3A 4的真实的催化活性。
Bufalin 5 beta-hydroxylation was found to be an isoform-specific biotransformation probe substrate for cytochrome P450 3A4 (CYP3A4). The probe reaction was well-characterized and it can be used for measuring the real catalytic activities of CYP3A4 from different enzyme sources.