[What do we know about anesthetic mechanisms?: hypnosis, unresponsiveness to surgical incision and amnesia].

[What do we know about anesthetic mechanisms?: hypnosis, unresponsiveness to surgical incision and amnesia].
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DOI:
10.1007/s00101-009-1618-9
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发表时间:
2009-11
期刊:
影响因子:
--
通讯作者:
Todorovic, S. M.
Todorovic, S. M.
中科院分区:
医学4区
文献类型:
--
作者:
Eckle, V. -S.;Hucklenbruch, C.;Todorovic, S. M.

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尽管过去几十年麻醉研究中的分子知识不断增加,但关于麻醉机制的讨论仍在继续。本文重点介绍麻醉敏感配体和电压门控离子通道。总结了临床常用麻醉药异氟烷、异丙酚和氯胺酮对麻醉调节离子通道的影响。此外,还简要介绍了麻醉的催眠、对手术切口反应迟钝和遗忘的特点及其在中枢神经系统中假定的相关解剖部位。
Despite the increase of molecular knowledge in anesthesia research over the past decades there is still ongoing discussion about the mechanisms of anesthesia. This article focuses on presenting anesthetic sensitive ligand and voltage gated ion channels. The impact on anesthetic modulated ion channels is summarized for clinically commonly used anesthetics isoflurane, propofol and ketamine. Furthermore, the anesthetic features hypnosis, unresponsiveness to surgical incision and amnesia and their putative relevant anatomical sites in the central nervous system are briefly introduced.
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