Post-translation Control of Nramp Metal Transport in Yeast
Post-translation Control of Nramp Metal Transport in Yeast
复制标题
酵母中 Nramp 金属转运的翻译后控制
DOI：
--
复制
发表时间：
1999
影响因子：
4.8
通讯作者：
V. Culotta
中科院分区：
文献类型：
--
作者：
Xiuying Liu;V. Culotta
The Saccharomyces cerevisiae SMF1gene encodes a member of the well conserved family of Nramp metal transport proteins. Previously, we determined that heavy metal uptake by Smf1p was down-regulated by the product of the S. cerevisiae BSD2 gene. We now demonstrate that this regulation occurs at the level of protein stability. In wild type strains, the bulk of Smf1p is normally directed to the vacuole and is rapidly degraded by vacuolar proteases in a PEP4-dependent manner. Inbsd2Δ mutants, Smf1p fails to enter the vacuole, and the Nramp protein is stabilized. Metal ions themselves play an important role in the post-translational regulation of Smf1p. The depletion of heavy metals from the growth medium effects stabilization of Smf1p and additionally results in accumulation of this transporter at the cell surface. Supplementation of manganese alone is sufficient to trigger rapid degradation of Smf1p in a Bsd2p-dependent manner. Together the action of Bsd2p and metal ions provide a rapid and effective means for controlling Nramp metal transport in response to environmental changes.
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影响因子：
4.4
作者：
GRUENHEID, S;CELLIER, M;GROS, P
通讯作者：
GROS, P
DOI：
10.1073/pnas.92.22.10089
发表时间：
1995-10-24
影响因子：
11.1
作者：
CELLIER, M;PRIVE, G;GROS, P
通讯作者：
GROS, P
DOI：
10.1073/pnas.95.3.1148
发表时间：
1998-02-03
影响因子：
11.1
作者：
Fleming, MD;Romano, MA;Andrews, NC
通讯作者：
Andrews, NC
酿酒酵母中的三个蛋白水解系统。
DOI：
--
发表时间：
1991
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Jones,EW
通讯作者：
Jones,EW
DOI：
10.1073/pnas.94.11.5550
发表时间：
1997-05-27
影响因子：
11.1
作者：
Graden, JA;Winge, DR
通讯作者：
Winge, DR