Results of a Community-Based Antiretroviral Treatment Program for HIV-1 Infection in Western Uganda
Results of a Community-Based Antiretroviral Treatment Program for HIV-1 Infection in Western Uganda
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DOI：
10.2174/157016210790442722
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发表时间：
2010-03-01
影响因子：
1
通讯作者：
Kiweewa, Francis
中科院分区：
文献类型：
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作者：
Kipp, Walter;Konde-Lule, Joseph;Kiweewa, Francis
目的：比较同一地区农村社区 ART (CBART) 计划与医院 ART 计划的治疗结果和死亡率。 方法：研究设计是一项非随机队列研究，由 CBART 队列中的 185 名 HIV 感染者 (PLWHIV) 和医院队列中的 200 名 PLWHIV 患者组成。这两个队列的资格是：感染 HIV 并有资格接受 ART、未接受过治疗、年龄 18 岁或以上、并且是 Rwimi 县的居民。干预措施包括一项以社区为基础的计划，其中包括训练有素的志愿者每周对患者进行家访，提供抗逆转录病毒药物（ARV），监测和支持治疗依从性，并识别和报告不良反应和其他临床症状。结果变量与接受医院所有其他艾滋病毒患者标准护理的医院队列患者进行比较。主要结果指标是 HIV-1 RNA 病毒载量 (VL)、CD4 细胞计数和治疗六个月后的死亡率。 结果：通过病毒学抑制 (VL) 衡量成功的 ART 治疗结果
Objective: To compare the treatment outcomes and mortality in a rural community-based ART (CBART) program with a hospital-based ART program in the same district.Methods: The study design was a non-randomized cohort study consisting of 185 persons living with HIV (PLWHIV) in the CBART cohort and 200 PLWHIV in the hospital cohort. Eligibility for both cohorts was: being HIV-infected and eligible for ART, being treatment naive, age 18 years or older, and being a resident of Rwimi sub-county. The intervention consisted of a community-based program which included weekly home visits to patients by trained volunteers who delivered antiretroviral drugs (ARVs), monitored and supported adherence to treatment, and identified and reported adverse reactions and other clinical symptoms. Outcome variables were compared to patients in a hospital-based cohort who received the standard care delivered to all other HIV patients in the hospital. The main outcome measures were HIV-1 RNA viral load (VL), CD4 cell count and mortality after six months of treatment.Results: Successful ART treatment outcome as measured by virological suppression (VL