Self-infusion of GABA(A) antagonists directly into the ventral tegmental area and adjacent regions
Self-infusion of GABA(A) antagonists directly into the ventral tegmental area and adjacent regions
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DOI：
10.1037/0735-7044.111.2.369
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发表时间：
1997-04-01
影响因子：
1.9
通讯作者：
McBride, WJ
中科院分区：
文献类型：
--
作者：
Ikemoto, S;Murphy, JM;McBride, WJ
本研究采用大鼠脑内自我给药模式，以确定腹侧被盖区（VTA）GAB AA受体的阻断是否具有强化作用。大鼠很快学会将印防己毒素溶液自行注入腹侧被盖区前部;大鼠区分产生印防己毒素输注的杠杆和无后果的杠杆;当反应要求增加时，大鼠增加印防己毒素输注的反应水平。印防己毒素的强化作用是位点特异性的：前腹侧被盖区支持有力的自我输液，但不是后腹侧被盖区，黑质，或外侧下丘脑。蝇蕈醇，一种GABAA激动剂，破坏印防己毒素自输注，但荷包牡丹碱，一种GABAA拮抗剂，自输注到VTA。结果表明，GABAA受体在前腹侧被盖区的封锁是加强和GABA系统内的腹侧被盖区的功能组织是异质性的。
This study used an intracerebral self-administration paradigm in rats to determine if blockade of GAB AA receptors in the ventral tegmental area (VTA) has a reinforcing effect. Rats quickly learned to self-infuse a picrotoxin solution into the anterior VTA; rats discriminated the lever that produced picrotoxin infusions from the lever without consequences; and when the response requirement was increased, rats increased response levels for picrotoxin infusion. The reinforcing effect of picrotoxin was site-specific: Anterior VTA regions supported vigorous self-infusions, but not the posterior VTA, substantia nigra, or lateral hypothalamus. Muscimol, a GABAA agonist, disrupted picrotoxin self-infusion, but bicuculline, a GABAA antagonist, was self-infused into the VTA. The results suggest that blockade of GABAA receptors in the anterior VTA is reinforcing and that functional organization of the GABA systems within the VTA is heterogeneous.