CEREBRAL BLOOD-FLOW DETERMINATION BY RAPID-SEQUENCE COMPUTED-TOMOGRAPHY - A THEORETICAL-ANALYSIS
CEREBRAL BLOOD-FLOW DETERMINATION BY RAPID-SEQUENCE COMPUTED-TOMOGRAPHY - A THEORETICAL-ANALYSIS
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DOI：
10.1148/radiology.137.3.7003648
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发表时间：
1980-01-01
期刊：
影响因子：
19.7
通讯作者：
AXEL, L
中科院分区：
文献类型：
--
作者：
AXEL, L
使用快速序列扫描的动态计算机断层扫描（CT）可用于在静脉推注造影剂后无创地确定脑血流。由于造影剂在正常大脑中保持在血管内，因此将非扩散性指示剂的指示剂稀释分析原理应用于造影剂浓度变化的时间过程。相对延长的静脉注射会引起延迟。如果在扫描中看到动脉，则可以纠正这种情况。团注首次通过血管的校正平均通过时间给出了每单位血管体积的血流量。为了找到每单位总组织体积的血流量，需要测量血液中造影剂的浓度，而这并不总是能用现有的CT设备直接从脑部扫描中完成。总组织流量的相对值可以通过使用作为时间的函数的造影剂浓度曲线下的面积来找到。该面积与组织的血管体积分数成比例。
Dynamic computed tomography (CT) using rapid-sequence scanning can be used to determine cerebral blood flow noninvasively following an i.v. bolus injection of contrast material. Since the contrast material remains intravascular in the normal brain, principles of indicator dilution analysis for nondiffusible indicators are applied to the time course of the changes in contrast concentration. A delay is introduced by the relatively prolonged i.v. injection. This can be corrected if the arteries are seen on the scan. The corrected mean transit time of the 1st passage of the bolus through the vessels gives the blood flow per unit vascular volume. To find the blood flow per unit of total tissue volume requires measuring the concentration of contrast material in the blood, which cannot always be done directly from brains scans with current CT equipment. A relative value for total tissue flow can be found by using the area under the curve of contrast concentration as a function of time. This area is proportional to the fractional vascular volume of the tissue.