Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium.
Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium.
复制标题
慢性休闲身体不活动和上皮卵巢癌风险：卵巢癌协会联盟的证据。
DOI：
10.1158/1055-9965.epi-15-1330
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Moysich KB
中科院分区：
文献类型：
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作者：
Cannioto R;LaMonte MJ;Risch HA;Hong CC;Sucheston-Campbell LE;Eng KH;Brian Szender J;Chang-Claude J;Schmalfeldt B;Klapdor R;Gower E;Minlikeeva AN;Zirpoli GR;Bandera EV;Berchuck A;Cramer D;Doherty JA;Edwards RP;Fridley BL;Goode EL;Goodman MT;Hogdall E;Hosono S;Jensen A;Jordan S;Australian Ovarian Cancer Study Group;Kjaer SK;Matsuo K;Ness RB;Olsen CM;Olson SH;Leigh Pearce C;Pike MC;Anne Rossing M;Szamreta EA;Thompson PJ;Tseng CC;Vierkant RA;Webb PM;Wentzensen N;Wicklund KG;Winham SJ;Wu AH;Modugno F;Schildkraut JM;Terry KL;Kelemen LE;Moysich KB
尽管有大量文献评估休闲体育活动与上皮性卵巢癌(EOC)风险之间的关系，但现有的证据并不确凿，而且对休闲体育活动不足与EOC风险之间的独立关联知之甚少。我们对来自卵巢癌协会联合会(OCAC)的9项研究进行了综合分析，以调查慢性休闲体育锻炼不足与EoC风险之间的关系。根据2008年美国人体力活动指南，报告没有定期、每周进行娱乐性体力活动的女性被归类为不活跃。采用多变量Logistic回归分析不活动与EoC风险相关的优势比(OR)和95%可信区间(CI)，并根据组织类型、绝经状态、种族和体重指数(BMI)进行分组。目前的分析包括8,309名EOC患者和12,612名对照的数据。我们观察到不活动与EOC风险呈显著正相关(OR=1.34，95%CI：1.14-1.57)，并且每种组织类型的相关性相似。在这项大规模的综合分析中，我们观察到了长期缺乏运动与所有EoC组织类型之间存在关联的一致证据，以检验休闲体育缺乏活动与EoC风险之间的关联。这些数据增加了越来越多的证据表明，缺乏运动是癌症的一个独立风险因素。如果不活动与EoC风险之间的明显关联得到证实，则应通过有针对性的干预进行额外的工作，以确定降低这种高度致命疾病的风险所需的活动剂量。
Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium (OCAC) to investigate the association between chronic recreational physical inactivity and EOC risk. In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the odds ratios (OR) and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race and body mass index (BMI). The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR=1.34, 95% CI: 1.14-1.57) and similar associations were observed for each histotype. In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes. These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease.