A case-control study of occupational exposures and systemic sclerosis
A case-control study of occupational exposures and systemic sclerosis
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DOI：
10.1007/s00420-003-0462-5
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发表时间：
2004-01-01
影响因子：
3
通讯作者：
Caramaschi, P
中科院分区：
文献类型：
--
作者：
Bovenzi, M;Barbone, F;Caramaschi, P
目标.在意大利维罗纳进行了一项病例对照研究，以评估职业、职业暴露与系统性硬化症（SSc）之间的关系。方法.招募了55例（46名女性和9名男性）和171名对照。访谈提供了工作历史，包括职称，行业和职业暴露于二氧化硅，手臂振动，有机溶剂和其他化学品的可能性。估计比值比（OR）和95%置信区间（95%CI）。结果女教师（OR 3.4，95% CI 1.2-10.1）和纺织工人（OR 2.1，95% CI 1.0-4.6）的SSc风险增加。与从未暴露的受试者相比，暴露于有机溶剂的受试者的年龄校正和性别校正OR为2.3（95% CI 1.0-5.4），暴露于选定化学品的受试者为2.5（95% CI 0.8-8.0），暴露于二氧化硅的受试者为1.7（95% CI 0.4-7.6），使用振动工具的受试者为1.5（95% CI 0.5-4.8）。当数据分析按性别分层时，只有男性暴露于溶剂和选定化学品的风险显着增加。结论.这项研究的结果往往支持的作用，有机溶剂和某些化学品的SSc的原因。与纺织行业的教学和工作的关联表明，其他暴露也涉及妇女SSc的病因。然而，由于受试者数量较少，特别是在分层分析中，不能排除偶然性作为本研究某些结果的解释。
Objectives. A case-control study was conducted in Verona, Italy, to assess the relationship between occupation, occupational exposures and systemic sclerosis (SSc). Methods. Fifty-five cases (46 female and nine male) and 171 controls were recruited. Interviews provided work histories, including job titles, industry and likelihood of occupational exposure to silica, hand-arm vibration, organic solvents, and other chemicals. Odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated. Results. Female teachers (OR 3.4, 95% CI 1.2-10.1) and textile workers (OR 2.1, 95% CI 1.0-4.6) were at an increased risk of SSc. Compared with those never exposed, age-adjusted and gender-adjusted ORs were 2.3 (95% CI 1.0-5.4) among subjects exposed to organic solvents, 2.5 (95% CI 0.8-8.0) for exposure to selected chemicals, 1.7 (95% CI 0.4-7.6) for exposure to silica, and 1.5 (95% CI 0.5-4.8) for usage of vibrating tools. When data analysis was stratified according to gender, only men showed a significant increase in risk for exposure to solvents and selected chemicals. Conclusions. The findings of this study tend to support the role of organic solvents and certain chemicals in SSc causation. The association with teaching and working in the textile industry suggests that other exposures are involved in the aetiology of SSc among women. However, because of the small number of subjects, particularly in stratified analyses, chance cannot be ruled out as an explanation of some findings of this study.