A Summary of Pathways or Mechanisms Linking Preconception Maternal Nutrition with Birth Outcomes
A Summary of Pathways or Mechanisms Linking Preconception Maternal Nutrition with Birth Outcomes
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DOI：
10.3945/jn.115.223479
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发表时间：
2016-07-01
影响因子：
4.2
通讯作者：
King, Janet C.
中科院分区：
文献类型：
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作者：
King, Janet C.
人口、人类、动物、组织和分子研究共同一致地表明，母体在孕前或围产期的营养会影响胎儿的生长和发育，从而影响个体的长期健康。众所周知，怀孕期间的营养是后代生长和健康的重要决定因素。然而，现在有证据表明，母亲在怀孕时的营养状况也会影响怀孕结果和长期健康。例如，母亲在怀孕时的营养状况会影响能量在母亲和胎儿需求之间的分配方式。此外，妊娠前几周的胎盘发育反映了母体营养状况，并建立了平衡母体和胎儿营养需求的机制。此外，母体受精时的营养信号影响胎儿基因的表观遗传重塑。这些发现都表明，母亲的养育在怀孕之前就开始了。在2015年科学会议和年度会议上提交的关于孕前营养的研讨会的以下论文强调了怀孕时产妇营养对儿童生长和长期健康的重要性。
Population, human, animal, tissue, and molecular studies show collectively and consistently that maternal nutrition in the pre- or periconception period influences fetal growth and development, which subsequently affects the individual's long-term health. It is known that nutrition during pregnancy is an important determinant of the offspring's growth and health. However, now there is evidence that the mother's nutritional status at conception also influences pregnancy outcome and long-term health. For example, the mother's nutritional status at conception influences the way energy is partitioned between maternal and fetal needs. Furthermore, placental development during the first weeks of gestation reflects maternal nutrition and establishes mechanisms for balancing maternal and fetal nutritional needs. Also, maternal nutritional signals at fertilization influence epigenetic remodeling of fetal genes. These findings all indicate that maternal parenting begins before conception. The following papers from a symposium on preconception nutrition presented at the 2015 Scientific Sessions and Annual Meeting of the ASN emphasize the importance of maternal nutrition at conception on the growth and long-term health of the child.