Regulatory elements in the viral genome
Regulatory elements in the viral genome
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DOI：
10.1016/j.virol.2013.04.035
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发表时间：
2013-10-01
期刊：
影响因子：
3.7
通讯作者：
Bernard, Hans-Ulrich
中科院分区：
文献类型：
--
作者：
Bernard, Hans-Ulrich
乳头瘤病毒的小DNA基因组含有数量惊人的调节或顺式反应元件，它们调节病毒的复制和转录，并控制细节，如对某些上皮细胞的特异性、对鳞状上皮层的特异性、反馈机制以及宿主细胞生理学和病毒生物学之间的耦合。这些元件大多数出现在长控制区，而其他元件则位于基因组的其他位置。许多乳头瘤病毒显示出相似的顺式反应元件组成，尽管这些元件是分散的并且不以序列相似性的长片段出现。这篇综述总结了我们对几种经过充分研究的α乳头瘤病毒类型的调控元件的了解，并指出了与其他乳头瘤病毒属的一些相似之处，但这些病毒属的特性仍知之甚少。 (C) 2013 Elsevier Inc. 保留所有权利。
The small DNA genomes of papillomaviruses contain a surprisingly large number of regulatory or cis-responsive elements, which regulate replication and transcription of the virus, and control details like specificity for certain epithelial cells, specificity for layers in squamous epithelia, feedback mechanisms and coupling between host cell physiology and virus biology. Most of these elements occur in the long control region, while others are located elsewhere in the genome. Many papillomaviruses show a similar composition of cis-responsive elements, although these are scattered and do not occur as long segments of sequence similarity. This review summarizes our knowledge of the regulatory elements in several well-studied Alphapapillomavirus types, and indicates some similarities to other papillomavirus genera, whose properties are yet poorly understood. (C) 2013 Elsevier Inc. All rights reserved.