Optimizing therapeutic efficacy of chemopreventive agents: A critical review of delivery strategies in oral cancer chemoprevention clinical trials.
Optimizing therapeutic efficacy of chemopreventive agents: A critical review of delivery strategies in oral cancer chemoprevention clinical trials.
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DOI：
10.4103/1477-3163.85185
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发表时间：
2011
影响因子：
--
通讯作者：
Mallery SR
中科院分区：
文献类型：
--
作者：
Holpuch AS;Desai KG;Schwendeman SP;Mallery SR
由于其特征性的进展从公认的癌前口腔上皮变化（即，口腔上皮异型增生）到浸润性癌症，口腔鳞状细胞癌代表了在恶性转化之前进行化学预防干预的最佳疾病。口腔癌化学预防的主要目标是逆转、抑制或抑制癌前病变向癌症的进展。在过去的几十年里，许多口腔癌化学预防临床试验已经评估了不同化学预防剂的治疗效果。更晚期口腔异型增生病变的标准治疗需要手术切除和密切的临床随访，因为在相似或更晚期的组织学阶段有可能发生局部复发（约33%）。本综述的目的是确定突出的口腔癌化学预防的临床试验，评估其整体治疗效果，并描绘局部与全身给药的影响。此外，这些汇编的临床试验数据提出了在未来临床试验的设计和实施中考虑的概念。
Due to its characterized progression from recognized premalignant oral epithelial changes (i.e., oral epithelial dysplasia) to invasive cancer, oral squamous cell carcinoma represents an optimal disease for chemopreventive intervention prior to malignant transformation. The primary goal of oral cancer chemoprevention is to reverse, suppress, or inhibit the progression of premalignant lesions to cancer. Over the last several decades, numerous oral cancer chemoprevention clinical trials have assessed the therapeutic efficacy of diverse chemopreventive agents. The standard of care for more advanced oral dysplastic lesions entails surgical excision and close clinical follow-up due to the potential (~33%) for local recurrence at a similar or more advanced histological stage. The purpose of this review was to identify prominent oral cancer chemoprevention clinical trials, assess their overall therapeutic efficacy, and delineate effects of local versus systemic drug administration. In addition, these compiled clinical trial data present concepts for consideration in the design and conduction of future clinical trials.