Alzheimer's disease: pathological mechanisms and recent insights.
Alzheimer's disease: pathological mechanisms and recent insights.
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DOI：
10.2174/157015911798376181
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发表时间：
2011-12
影响因子：
5.3
通讯作者：
Murphy MP
中科院分区：
文献类型：
--
作者：
Niedowicz DM;Nelson PT;Murphy MP
淀粉样病变引起神经退行性变在老年人的相当一部分。长期保健的改善使老年人成为一个庞大且不断增长的人口群体，使这些疾病成为一个主要的公共卫生问题。阿尔茨海默病（AD）是研究最多的神经退行性淀粉样病变。尽管我们对阿尔茨海默病的了解还远远不够，但几十年的研究已经使我们的知识进步到可以想象的程度，在不久的将来，某种形式的疾病修饰疗法可能会出现。这些进展是建立在从其潜在的遗传学、分子生物学和临床病理学对该疾病的强大机制理解的基础上的。从其他神经退行性疾病（如某些形式的额颞叶痴呆）的研究中获得的见解对这一过程至关重要。这些知识使研究人员能够构建疾病过程的动物模型，为治疗方法的发展铺平了道路。然而，曾经被认为是一个直截了当的问题已经演变成一系列令人失望的结果。检查所有神经退行性疾病的共同途径，包括清除错误折叠蛋白质及其调节的细胞机制，可能是向前发展的最佳途径。
Amyloidopathies cause neurodegeneration in a substantial portion of the elderly population. Improvements in long term health care have made elderly individuals a large and growing demographic group, marking these diseases as a major public health concern. Alzheimer’s Disease (AD) is the most studied form of neurodegenerative amyloidopathy. Although our understanding of AD is far from complete, several decades of research have advanced our knowledge to the point where it is conceivable that some form of disease modifying therapy may be available in the near future. These advances have been built on a strong mechanistic understanding of the disease from its underlying genetics, molecular biology and clinical pathology. Insights derived from the study of other neurodegenerative diseases, such as some forms of frontotemporal dementia, have been critical to this process. This knowledge has allowed researchers to construct animal models of the disease process that have paved the way towards the development of therapeutics. However, what was once thought to be a straightforward problem has evolved into a series of disappointing outcomes. Examination of pathways common to all neurodegenerative diseases, including the cellular mechanisms that clear misfolded proteins and their regulation, may be the best way to move forward.