Global Tactile Coding in Rat Barrel Cortex in the Absence of Local Cues

Global Tactile Coding in Rat Barrel Cortex in the Absence of Local Cues
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在缺乏局部线索的情况下,大鼠桶状皮层的全局触觉编码

DOI:
10.1093/cercor/bhx108
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发表时间:
2015
期刊:
影响因子:
3.7
通讯作者:
Schwarz
Schwarz
中科院分区:
医学2区
文献类型:
--
作者:
Gerdjikov;Bergner;Schwarz

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虽然胡须相关的感知主要是基于本地,近瞬时编码,全球,密集的编码,随着时间的推移,集成的振动触觉信号,也已被证明发挥作用,适当的行为条件。在这里,我们研究全球编码隔离研究头部固定的大鼠,确定脉冲刺激不同的脉冲频率,但不是在脉冲波形,从而废除了基于本地编码的看法。我们量化了时间锁定和尖峰计数作为支持2种编码方案的可能变量。这两个神经测量变量包含大量的刺激信息,甚至单桶皮层神经元的尖峰。为了阐明哪种类型的信息实际上是由大鼠使用,我们系统地比较了心理测量与神经测量的敏感性的基础上的2个编码方案。神经测量性能的计算,通过使用人口编码模型,结合我们记录的神经元样本的属性。我们发现,从长时间(>1 s)采样的尖峰计数计算的灵敏度与大鼠的表现相匹配,而不是与刺激时间锁定的尖峰所携带的灵敏度。我们的结论是,尖峰计数更相关的触觉感知时,瞬时运动参数不可用。
Although whisker-related perception is based predominantly on local, near-instantaneous coding, global, intensive coding, which integrates the vibrotactile signal over time, has also been shown to play a role given appropriate behavioral conditions. Here, we study global coding in isolation by studying head-fixed rats that identified pulsatile stimuli differing in pulse frequency but not in pulse waveforms, thus abolishing perception based on local coding. We quantified time locking and spike counts as likely variables underpinning the 2 coding schemes. Both neurometric variables contained substantial stimulus information, carried even by spikes of single barrel cortex neurons. To elucidate which type of information is actually used by the rats, we systematically compared psychometric with neurometric sensitivity based on the 2 coding schemes. Neurometric performance was calculated by using a population-encoding model incorporating the properties of our recorded neuron sample. We found that sensitivity calculated from spike counts sampled over long periods (>1 s) matched the performance of rats better than the one carried by spikes time-locked to the stimulus. We conclude that spike counts are more relevant to tactile perception when instantaneous kinematic parameters are not available.
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