MRI neuroanatomy in young girls with autism: A preliminary study
MRI neuroanatomy in young girls with autism: A preliminary study
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DOI：
10.1097/chi.0b013e318030e28b
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发表时间：
2007-04-01
影响因子：
13.3
通讯作者：
Courchesne, Eric
中科院分区：
文献类型：
--
作者：
Bloss, Cinnamon S.;Courchesne, Eric
目的：验证以下假设：自闭症的年轻女孩和男孩表现出不同的神经解剖学异常，相对于彼此和相对于典型发育的儿童。方法：对9例女性(2.29~5.16岁)和27例男性(1.96~5.33岁)孤独症患者和14例女性(2.17~5.71岁)和13例男性(1.72~5.50岁)发育正常的自闭症患者进行结构磁共振成像测量灰质、白质体积(全脑、脑叶、小脑)和总脑体积。观察结构大小及大小与年龄的关系。诊断和认知结果数据是在儿童4-5岁后获得的。结果：与患有自闭症的男孩相比，患有自闭症的女孩几乎表现出与体型相关的所有异常。此外，在女孩身上还观察到了其他异常部位，包括颞叶白质和灰质体积增大，小脑灰质体积减小。自闭症女孩的年龄与脑白质体积显著相关(例如，脑白质r(S)=0.950)，而男孩的年龄-结构大小关系不显著。结论：本研究结果提示本病的病因和生物学时程存在性别差异。
Objective: To test the hypothesis that young girls and boys with autism exhibit different profiles of neuroanatomical abnormality relative to each other and relative to typically developing children. Method: Structural magnetic resonance imaging was used to measure gray and white matter volumes (whole cerebrum, cerebral lobes, and cerebellum) and total brain volume in nine girls (ages 2.29-5.16) and 27 boys (ages 1.96-5.33) with autism and 14 girls (ages 2.17-5.71) and 13 boys (ages 1.72-5.50) with typical development. Structure size and the relationship between size and age were examined. Diagnostic and cognitive outcome data were obtained after the children reached 4 to 5 years of age. Results: Girls with autism exhibited nearly every size-related abnormality exhibited by boys with autism. Furthermore, additional sites of abnormality were observed in girls, including enlargement in temporal white and gray matter volumes and reduction in cerebellar gray matter volume. Significant correlations were observed between age and white matter volumes (e.g., cerebral white matter r(s) = 0.950) for the girls with autism, whereas no significant age-structure size relationships were observed for the boys with autism. Conclusions: Results suggest sex differences in etiological factors and the biological time course of the disorder.