Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations.
Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations.
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视神经脊髓炎谱系疾病的复杂性和广泛性：不仅仅是典型的表现
DOI：
10.2147/ndt.s147360
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发表时间：
2017
影响因子：
3.2
通讯作者：
Jin T
中科院分区：
文献类型：
--
作者：
Han J;Yang MG;Zhu J;Jin T
视神经肌萎缩症（NMO）被认为是由自身抗体介导的，通常引起严重的中枢神经系统致残性疾病，并且主要引起视神经损伤和纵向广泛的横肌萎缩。在过去的十年中，在解释NMO发病机制方面取得了显着进展。2015年，国际NMO诊断小组提出了统一术语“NMO谱系障碍”（NMOSD），更新的NMOSD标准反映了广泛的疾病并保持了合理的特异性。此外，累积的研究结果表明，NMOSD经常与多种自身免疫性疾病相关，从而呈现复杂的临床症状，使这种疾病更难以识别。值得注意的是，大多数神经科医生不注意NMOSD患者的这些症状或合并症。鉴于以前的审查集中在NMOSD的发病机制，治疗和预后，我们总结了目前的知识，特别强调非典型表现和自身免疫性合并症的NMOSD患者。此外，我们强调了这些非典型特征的识别，以使更广泛和更好地了解NMOSD，并提高早期准确诊断和治疗决策。
Neuromyelitis optica (NMO), considered to be mediated by autoantibodies, often cause severely disabling disorders of the central nervous system, and predominantly cause optic nerve damage and longitudinally extensive transverse myelitis. Remarkable progress has been made in deciphering NMO pathogenesis during the past decade. In 2015, the International Panel for NMO Diagnosis proposed the unifying term “NMO spectrum disorders” (NMOSD) and the updated NMOSD criteria reflects a wide range of disease and maintains reasonable specificity. Moreover, cumulative findings have indicated that NMOSD are frequently associated with multiple autoimmune diseases, thereby presenting complex clinical symptoms that make this disease more difficult to recognize. Notably, most neurologists do not heed these symptoms or comorbid conditions in patients with NMOSD. Whereas previous reviews have focused on pathogenesis, treatment, and prognosis in NMOSD, we summarize the present knowledge with particular emphasis on atypical manifestations and autoimmune comorbidities in patients with NMOSD. Furthermore, we emphasized the identification of these atypical characteristics to enable a broader and better understanding of NMOSD, and improve early accurate diagnosis and therapeutic decision making.