Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
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DOI：
10.1074/jbc.m407732200
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发表时间：
2004-10-08
影响因子：
4.8
通讯作者：
Dower, SK
中科院分区：
文献类型：
--
作者：
Kiss-Toth, E;Bagstaff, SM;Dower, SK
丝裂原激活蛋白激酶 (MAPK) 级联的控制对于许多细胞反应的调节至关重要。我们在这里描述了控制 MAPK 活性的人类 tribbles 同源物 (Htrbs)。 MAPK 激酶与 Trb 相互作用并调节其稳态水平。此外，Trbs 选择性地调节细胞外信号调节激酶、c-Jun NH2 末端激酶和 p38 MAPK 的激活，根据 Trb 表达水平观察到的三类 MAPK 具有不同的相对活性水平。这些结果表明 Trbs 控制 MAPK 激酶激活的程度和特异性。
Control of mitogen-activated protein kinase ( MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with Trbs and regulate their steady state levels. Further, Trbs selectively regulate the activation of extracellular signal-regulated kinases, c-Jun NH2-terminal kinases, and p38 MAPK with different relative levels of activity for the three classes of MAPK observed depending on the level of Trb expression. These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK.