Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus
Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus
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焦虑的减少与暴露于金鱼的废水处理废水中六种血清素再摄取抑制剂的积累有关
作者：
Denina B.D. Simmons;Erin S. McCallum;S. Balshine;B. Chandramouli;John R. Cosgrove;J. Sherry
药物和个人护理产品（PPCPs）已被发现在污水处理厂（WWTP）的流出物及其接收流域。为了评估潜在的污水处理厂废水改变鱼的行为，我们笼雄性金鱼（鲫鱼）21天，在三个站点沿着污染梯度下游的污水处理厂排放到库茨天堂沼泽，在西端的安大略湖。我们还包括了第四笼网站作为外部参考网站内的安大略湖在约旦港保护区。然后，我们测量的PPCPs和单胺神经递质在笼子里的金鱼血浆的浓度，并进行行为测定测量活动，惊吓反应，和喂养。我们在金鱼血浆中检测到15种不同的PPCP，包括6种5-羟色胺再摄取抑制剂（阿米替林、西酞普兰、氟西汀/去甲氟西汀、舍曲林、文拉法辛和苯海拉明）。血浆中的血清素浓度显着更大的血浆中的鱼笼更接近污水处理厂污水排放口网站。在污水处理厂废水附近和下游的鱼笼更大胆，更具探索性，更积极的整体比鱼笼在参考网站。综上所述，我们的研究结果表明，污水处理厂下游的鱼类积累PPCPs的水平足以改变神经递质的浓度，也损害生态相关的行为。
Pharmaceuticals and personal care products (PPCPs) have been found in wastewater treatment plant (WWTP) effluents and their recipient watersheds. To assess the potential of WWTP effluents to alter fish behaviour, we caged male goldfish (Carassius auratus) for 21-days at three sites along a contamination gradient downstream from a WWTP which discharges into Cootes Paradise Marsh, on the western tip of Lake Ontario. We also included a fourth caging site as an external reference site within Lake Ontario at the Jordan Harbour Conservation Area. We then measured concentrations of PPCPs and monoamine neurotransmitters in caged goldfish plasma, and conducted behavioural assays measuring activity, startle response, and feeding. We detected fifteen different PPCPs in goldfish plasma including six serotonin reuptake inhibitors (amitriptyline, citalopram, fluoxetine/norfluoxetine, sertraline, venlafaxine, and diphenhydramine). Plasma concentrations of serotonin were significantly greater in plasma of fish caged closer to the WWTP effluent outfall site. The fish caged near and downstream of the WWTP effluent were bolder, more exploratory, and more active overall than fish caged at the reference site. Taken together, our results suggest that fish downstream of WWTPs are accumulating PPCPs at levels sufficient to alter neurotransmitter concentrations and to also impair ecologically-relevant behaviours.
影响因子：
11.4
作者：
Valenti TW;Gould GG;Berninger JP;Connors KA;Keele NB;Prosser KN;Brooks BW
通讯作者：
Brooks BW