Effectiveness of oseltamivir treatment among children with influenza A or B virus infections during four successive winters in Niigata city, Japan
Effectiveness of oseltamivir treatment among children with influenza A or B virus infections during four successive winters in Niigata city, Japan
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DOI：
10.1620/tjem.214.113
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发表时间：
2008-02-01
影响因子：
2.2
通讯作者：
Suzuki, Hiroshi
中科院分区：
文献类型：
--
作者：
Sato, Maki;Saito, Reiko;Suzuki, Hiroshi
奥司他韦已用于治疗甲型和乙型流感感染，但最近的报告表明，它对后者的活性较低。我们在日本一家儿科诊所比较了 2001 年至 2005 年 4 个流感季节中实验室确诊的甲型和乙型流感儿童中奥司他韦的有效性。在筛选的 1,848 名患者中，299 名甲型流感患者和 209 名乙型流感患者接受了奥司他韦治疗（治疗组），28 名甲型流感患者和 66 名乙型流感患者被分配为非治疗组。评估四组患者的发热持续时间，即患者就诊后一天内三次测量的最高体温高于37.5℃的时间。在单变量分析中，甲型流感治疗组的发烧持续时间比未治疗组短（1.8 +/- 0.9 天 vs 2.6 +/- 1.3 天，p < 0.01），但乙型流感则不显着（2.4 +/- 1.3 天 vs 2.8 +/- 1.2 天，p = 0.9）。接受治疗的乙型流感患者的发烧持续时间比甲型流感患者更长（p < 0.01）。多变量分析表明，就诊时年龄较小（< 6 岁）和较高体温会延长发烧持续时间。调整后的平均发烧持续时间表明，奥司他韦对两种类型的流感均有效，但对甲型流感更有效，并且对年幼儿童的益处更大。我们的数据提供证据表明奥司他韦对流感感染有益，但有效性因类型和年龄而异。
Oseltamivir has been used for treatment of influenza A and B infections, but recent reports documented that it was less active against the latter. We compared the effectiveness of oseltamivir in children between laboratory confirmed influenza A and B over 4 influenza seasons from 2001 to 2005 in a pediatric clinic in Japan. Among 1,848 patients screened, 299 influenza A and 209 influenza B patients were administered oseltamivir (treated groups), and 28 influenza A and 66 influenza B patients were assigned as non-treated groups. The duration of fever, defined as period when patients had the maximum temperature higher than 37.5 degrees C in three-time measurements in a day after the clinic visit, was evaluated among the four groups. In uni-variate analysis, the duration of fever was shorter for treated group than non-treated for influenza A (1.8 +/- 0.9 days vs 2.6 +/- 1.3 days, p < 0.01), but it was not significant for influenza B (2.4 +/- 1.3 days vs 2.8 +/- 1.2 days, p = 0.9). The fever duration was longer in treated influenza B than A patients (p < 0.01). Multi-variate analysis indicated younger age (< 6 years old) and higher body temperature at the clinic visit prolonged the duration of fever. Adjusted average duration of fever indicated that oseltatmivir was effective for both types, but more effective on influenza A, and the benefit increased for younger children. Our data provide evidence that oseltamivir is beneficial for influenza infections, but the effectiveness is differed by type and age.