New Insights into Control of Arbovirus Replication and Spread by Insect RNA Interference Pathways.
New Insights into Control of Arbovirus Replication and Spread by Insect RNA Interference Pathways.
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DOI：
10.3390/insects3020511
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发表时间：
2012-05-29
期刊：
影响因子：
3
通讯作者：
Schnettler E
中科院分区：
文献类型：
--
作者：
Donald CL;Kohl A;Schnettler E
节肢动物传播的病毒通过媒介（如蚊子）传播给易感脊椎动物。最近的研究表明，虫媒病毒在蚊子中的复制和传播不是被动耐受的，而是诱导宿主产生控制这些病原体的反应。小rna介导的宿主反应是这些抗病毒免疫策略中的关键角色。对其中一种小RNA介导的抗病毒反应——外源性RNA干扰（RNAi）途径的研究，已经产生了丰富的关于该机制的功能和介导抗病毒活性的酶的信息。然而，其他小rna介导的宿主反应也可能参与调节抗病毒活性。本文综述了蚊虫小rna介导的抗病毒反应性质的最新研究，并讨论了这一相对较新的研究领域的未来发展方向。
Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control these pathogens. Small RNA-mediated host responses are key players among these antiviral immune strategies. Studies into one such small RNA-mediated antiviral response, the exogenous RNA interference (RNAi) pathway, have generated a wealth of information on the functions of this mechanism and the enzymes which mediate antiviral activities. However, other small RNA-mediated host responses may also be involved in modulating antiviral activity. The aim of this review is to summarize recent research into the nature of small RNA-mediated antiviral responses in mosquitoes and to discuss future directions for this relatively new area of research.