Active C4 Electrodes for Local Field Potential Recording Applications.
Active C4 Electrodes for Local Field Potential Recording Applications.
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DOI：
10.3390/s16020198
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发表时间：
2016-02-04
期刊：
影响因子：
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通讯作者：
Knepper R
中科院分区：
文献类型：
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作者：
Wang L;Freedman D;Sahin M;Ünlü MS;Knepper R
多电极阵列细胞外神经记录是一种在网络水平上研究神经功能的有效方法。然而，在高密度阵列中，将有源电路与昂贵的电极集成可能是昂贵且耗时的。本文介绍了一种4 mm×4 mm神经记录集成电路芯片，该芯片采用IBM C4凸点作为记录电极，实现了有源芯片与电极的无缝集成。该芯片采用0.13μm BiCMOS体内外工艺进行设计和制造。在10 Hz至10μ的带宽范围内，其输入参考噪声为4.6kHz V，在2.5V时的功耗为11.25 mW，即每个输入通道的功耗为43.9μW。该样机可扩展用于实现更大数量和更高密度的电极阵列。为了验证芯片的功能，给出了电测试结果和大鼠桶状皮质的急性活体记录。
Extracellular neural recording, with multi-electrode arrays (MEAs), is a powerful method used to study neural function at the network level. However, in a high density array, it can be costly and time consuming to integrate the active circuit with the expensive electrodes. In this paper, we present a 4 mm × 4 mm neural recording integrated circuit (IC) chip, utilizing IBM C4 bumps as recording electrodes, which enable a seamless active chip and electrode integration. The IC chip was designed and fabricated in a 0.13 μm BiCMOS process for both in vitro and in vivo applications. It has an input-referred noise of 4.6 μV for the bandwidth of 10 Hz to 10 kHz and a power dissipation of 11.25 mW at 2.5 V, or 43.9 μW per input channel. This prototype is scalable for implementing larger number and higher density electrode arrays. To validate the functionality of the chip, electrical testing results and acute in vivo recordings from a rat barrel cortex are presented.