Causes of early mortality after liver transplantation: A twenty-years single centre experience
Causes of early mortality after liver transplantation: A twenty-years single centre experience
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DOI：
10.1016/j.annfar.2011.06.014
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发表时间：
2011-12-01
影响因子：
--
通讯作者：
Jaber, S.
中科院分区：
文献类型：
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作者：
Jung, B.;Cisse, M.;Jaber, S.
客观的。 - 确定肝移植后头三个月内死亡患者的死亡原因。研究类型。 - 回顾性、观察性和单中心研究。患者和方法。 - 1989年3月至2010年7月期间，所有肝移植后三个月内死亡的患者均被纳入。收集人口统计学特征、术前和术中数据、供者特征、术后并发症和死亡原因。结果。 - 在788例肝移植中，76例患者在重症监护室死亡（11%）。肝移植的主要适应症为酒精性肝硬化（30%）、丙型肝炎（28%）、肝癌（15%）、原发性或继发性胆汁性肝硬化（10%）。 50%的患者被归类为Child C。主要死亡原因是再移植禁忌证移植物无功能或功能障碍（18%）、败血症（18%）、神经系统并发症（12%）、失血性休克（13%）、（9%）、多器官功能衰竭（5%）、心脏并发症（6%）。结论。在这项研究中，死亡的主要原因是感染性、神经性和出血性。这些结果强调了更好地控制脓毒症、出血和免疫抑制剂的必要性。 (C) 2011 Elsevier Masson SAS。版权所有。
Objective. - To define the causes of mortality of patients who died within the first three months after a liver transplantation.Type of study. - Retrospective, observational, and single centre study.Patients and methods. - Between March 1989 and July 2010, all patients who died within three months after a liver transplantation were included. Demographic characteristics, preoperative and peroperative data, donor characteristics, postoperative complications and causes of mortality were collected.Results. - Among the 788 performed liver transplantations, 76 patients died in intensive care unit (11%). The main indications of liver transplantation were alcoholic cirrhosis (30%), hepatitis C (28%), hepatocarcinoma (15%), primitive or secondary biliary cirrhosis (10%). Fifty percent of the patients were categorized as Child C. The main causes of death were non-function or dysfunction with retransplantation contra-indication graft (18%), sepsis (18%), neurological complications (12%), hemorrhagic shock (13%), (9%), multiorgan failures (5%), cardiac complications (6%).Conclusion. In this study, the main causes of mortality were infectious, neurological and hemorrhagic. These results emphasize the necessity for better control of sepsis, haemorrhage and immunosupressors. (C) 2011 Elsevier Masson SAS. All rights reserved.