TUMORIGENIC TRANSFORMATION OF MAMMALIAN-CELLS INDUCED BY A NORMAL HUMAN-GENE HOMOLOGOUS TO THE ONCOGENE OF HARVEY MURINE SARCOMA-VIRUS
TUMORIGENIC TRANSFORMATION OF MAMMALIAN-CELLS INDUCED BY A NORMAL HUMAN-GENE HOMOLOGOUS TO THE ONCOGENE OF HARVEY MURINE SARCOMA-VIRUS
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DOI：
10.1038/297479a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
LOWY, DR
中科院分区：
文献类型：
--
作者：
CHANG, EH;FURTH, ME;LOWY, DR
与Harvey鼠肉瘤病毒的p21 ras癌基因同源的正常人基因在鼠成纤维细胞中诱导致癌转化和高p21 ras水平，当该基因与来自鼠或猫逆转录病毒的控制元件（长末端重复序列）连接时。由正常人类癌基因编码的高水平基因产物显然可以诱导致瘤性转化。
A normal human gene homologous to the p21 ras oncogene of Harvey murine sarcoma virus induced oncogenic transformation and high p21 ras levels in murine fibroblasts when this gene was ligated to a control element (the long terminal repeat) from a murine or feline retrovirus. That high levels of a gene product encoded by a normal human oncogene apparently can induce tumorigenic transformation.