Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder
Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder
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DOI：
10.1016/j.jpsychires.2010.04.020
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发表时间：
2011-01-01
影响因子：
4.8
通讯作者：
Mayberg, Helen S.
中科院分区：
文献类型：
--
作者：
Dunlop, Boadie W.;Betancourt, Yara;Mayberg, Helen S.
背景资料：地塞米松促肾上腺皮质激素释放激素（Dex-CRH）测试可以区别预测哪些抑郁症患者会对抗抑郁药物有反应。然而，一个全面的分析，这个测试在精神病patients.Methods的安全性以前没有进行：我们进行了汇总分析抑郁症患者在四个临床研究。在CRH给药后90分钟内收集了454例患者的观察和主观报告的副作用。250名患者的试验前心电图可用于评估心脏安全性。进行描述性统计，以评估这些安全性data.Results：八，六（18.9%）的主题经历了没有副作用的程序。每例受试者的平均副作用数量为1.4 ± 1.0。最常见的不良事件为：潮红（n = 216，47.6%）、温暖感（144，31.7%）、呼吸过度/呼吸急促（108，23.8%）、心悸（37，8.1%）和心动过速（28，6.2%）。副作用持续时间较短，持续时间较短。有没有严重的不良事件。结论：Dex-CRH测试产生一个温和的，可预测的副作用的配置文件，其特点是潮红，温暖的感觉，呼吸过度/呼吸急促，心悸，和心动过速。这些结果保证了Dex-CRH试验在精神病患者中的耐受性良好。(C)2010爱思唯尔有限公司保留所有权利。
Background: The dexamethasone corticotropin releasing hormone (Dex-CRH) test may differentially predict which depressed patients will respond to antidepressant medication. However, a comprehensive analysis of the safety of this test in psychiatric patients has not previously been performed.Methods: We conducted a pooled analysis of depressed patients in four clinical studies. Observed and subjectively reported side-effects in 454 patients were collected for 90 minutes following CRH-administration. Pre-test electrocardiograms were available in 250 patients to assess cardiac safety. Descriptive statistics were performed to evaluate these safety data.Results: Eight-six (18.9%) subjects experienced no side-effects from the procedure. The mean number of side-effects per subject was 1.4 +/- 1.0. The most frequent adverse events were: flushing (n = 216, 47.6%), feeling of warmth (144, 31.7%), hyperpnea/tachypnea (108, 23.8%), palpitations (37, 8.1%), and tachycardia (28, 6.2%). Side-effects were consistently mild and brief in duration. There were no serious adverse events.Conclusion: The Dex-CRH test produces a mild, predictable side-effect profile, characterized by flushing, feelings of warmth, hyperpnea/tachypnea, palpitations, and tachycardia. These results provide reassurance that the Dex-CRH test is well tolerated in psychiatric patients. (C) 2010 Elsevier Ltd. All rights reserved.