Psychological profile and α-amylase levels in oral lichen planus patients: A case-control preliminary study
Psychological profile and α-amylase levels in oral lichen planus patients: A case-control preliminary study
复制标题
DOI：
10.1111/odi.14081
复制
发表时间：
2021-12-05
期刊：
影响因子：
3.8
通讯作者：
Freitas, Valeria Souza
中科院分区：
文献类型：
--
作者：
da Silva Simoura, Juliana Araujo;Pinho Valente Pires, Alessandra Lais;Freitas, Valeria Souza
目的 调查与口腔扁平苔藓相关的心理（焦虑、抑郁和压力）和唾液（α-淀粉酶的流量和浓度）特征。材料和方法 对口腔扁平苔藓患者和年龄-性别匹配的对照进行了病例对照初步研究。参与者接受了心理测试（贝克抑郁和焦虑量表以及感知压力量表）和唾液采集，以确定一天中三个时刻未受刺激的唾液流量和α-淀粉酶水平。使用Mann-Whitney、McNemar 卡方和Friedman 检验以及Spearman 相关系数对数据进行统计分析。采用的显着性水平为5%。结果 总共招募了 46 对病例对照组。焦虑、抑郁、压力和口腔扁平苔藓以及压力和唾液α-淀粉酶水平下降之间存在显着相关性。在醒来后三十分钟的病例组中发现了较高浓度的这种生物标志物。结论应用心理测试表明焦虑、抑郁、应激等因素与口腔扁平苔藓有关。唾液分析表明，患有该疾病的个体在醒来后三十分钟内α-淀粉酶浓度较高，并且其下降与压力相关，这表明α-淀粉酶作为未来研究有前途的生物标志物的作用。
Objective To investigate psychological (anxiety, depression, and stress) and salivary (flow and concentration of alpha-amylase) profile associated with oral lichen planus. Materials and methods A case-control preliminary study with oral lichen planus patients and age-gender matched controls was conducted. The participants underwent psychological tests (Beck depression and anxiety inventories and perceived stress scale) and saliva collection to determine the unstimulated salivary flow and alpha-amylase levels at three moments along the day. The data were analyzed statistically using Mann-Whitney, McNemar chi-square and Friedman tests, and the Spearman correlation coefficient. The significance level adopted was 5%. Results A total of 46 case-control pairs were recruited. There was a significant correlation between anxiety, depression, stress, and oral lichen planus, as well as the stress and decline of salivary alpha-amylase levels. Higher concentrations of this biomarker were found in the case group thirty minutes post-awakening. Conclusion The applied psychological tests indicated that factors such as anxiety, depression, and stress were associated with oral lichen planus. Salivary analyses demonstrated a higher concentration of alpha-amylase thirty minutes post-awakening on individuals with the disease and its decline correlated with stress, suggesting the role of alpha-amylase as a promising biomarker for future studies.