Effects of sex and normal aging on regional brain activation during verbal memory performance
Effects of sex and normal aging on regional brain activation during verbal memory performance
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DOI：
10.1016/j.neurobiolaging.2008.10.005
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发表时间：
2010-05-01
影响因子：
4.2
通讯作者：
Buchsbaum, Monte S.
中科院分区：
文献类型：
--
作者：
Hazlett, Erin A.;Byne, William;Buchsbaum, Monte S.
本研究在70名20-87岁的健康正常成年人的言语记忆任务中，使用FDG-PET检查了年龄和性别对39个皮质Brodmann区（BA）和扣带回灰质内相对葡萄糖代谢率（rGMR）的主要影响和交互影响。女性左扣带回的年龄相关rGMR下降显著大于男性（BA 25，24，23，31，29）。两组都表现出前扣带回的下降，这是一种神经解剖结构，介导有效的认知-情感互动（BA 32，24，25），而其他额叶区域没有表现出实质性的下降。颞叶、顶叶和枕叶的rGMR无性别差异。扣带回亚成分内的rGMR存在性别差异，男性在BA 25和BA 29中较高，但在BA 24和BA 23中较低。对于男性来说，更好的记忆表现与BA 24中更大的rGMR相关，而在女性中，更好的记忆表现与眶额BA 12相关。这些结果表明，与年龄相关的代谢下降和性别差异的额叶区域内更显着的内侧额叶和扣带回区，与一些年龄相关的模式的情感和认知变化。(C)2008年爱思唯尔公司All rights reserved.
This study examined the main and interactive effects of age and sex on relative glucose metabolic rate (rGMR) within gray matter of 39 cortical Brodmann areas (BAs) and the cingulate gyrus using (18)FDG-PET during a verbal memory task in 70 healthy normal adults, aged 20-87 years. Women showed significantly greater age-related rGMR decline in left cingulate gyrus than men (BAs 25, 24, 23, 31, 29). Both groups showed a decline in the anterior cingulate a neuroanatomical structure that mediates effective cognitive-emotional interactions (BAs 32, 24, 25), while the other frontal regions did not show substantial decline. No sex differences in rGMR were identified within temporal, parietal and occipital lobes. Sex differences were observed for rGMR within subcomponents of the cingulate gyrus with men higher in BA25 and BA29, but lower in BA24 and BA 23 compared to women. For men, better memory performance was associated with greater rGMR in BA24, whereas in women better performance was associated with orbitofrontal-BA12. These results suggest that both age-related metabolic decline and sex differences within frontal regions are more marked in medial frontal and cingulate areas, consistent with some age-related patterns of affective and cognitive change. (C) 2008 Elsevier Inc. All rights reserved.