In Vivo Wall Shear Stress Distribution in the Carotid Artery Effect of Bifurcation Geometry, Internal Carotid Artery Stenosis, and Recanalization Therapy
In Vivo Wall Shear Stress Distribution in the Carotid Artery Effect of Bifurcation Geometry, Internal Carotid Artery Stenosis, and Recanalization Therapy
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DOI：
10.1161/circimaging.110.958504
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发表时间：
2010-11-01
影响因子：
7.5
通讯作者：
Harloff, Andreas
中科院分区：
文献类型：
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作者：
Markl, Michael;Wegent, Felix;Harloff, Andreas
背景-本研究的目的是分析颈动脉分叉处的绝对壁面剪切应力（WSS（abs））和振荡剪切指数（OSI）的体内分布，并评估其对分叉几何形状、颈内动脉（伊卡）狭窄的存在、方法和结果-时间分辨三维血流获得与流动-对64例正常颈动脉分叉和17例伊卡狭窄（48 ± 6%）或手术再通后的颈动脉进行敏感的4D MRI。在64个正常动脉中，致动脉粥样硬化壁参数始终集中在颈总动脉（CCA）和颈内动脉（伊卡）的近端球区域。暴露于易动脉粥样硬化壁参数（低于组定义的20%和10%阈值的低WSS（abs）和高于组定义的20%和10%阈值的高OSI）的颈动脉球分数与个体分叉几何形状相关。多元回归分析显示，
Background-The purpose of this study was to analyze the in vivo distribution of absolute wall shear stress (WSS(abs)) and oscillatory shear index (OSI) in the carotid bifurcation and to evaluate its dependence on bifurcation geometry, the presence of internal carotid artery (ICA) stenosis, and recanalization therapy.Methods and Results-Time-resolved 3D blood flow was acquired with flow-sensitive 4D MRI in 64 normal carotid bifurcations and 17 carotid arteries with moderate ICA stenosis (48 +/- 6%) or after surgical recanalization. Among 64 normal arteries, atherogenic wall parameters were consistently concentrated in proximal bulb regions of the common (CCA) and internal (ICA) carotid arteries. The fraction of the carotid bulb exposed to atherosclerosis-prone wall parameters (low WSS(abs) below and high OSI above group-defined 20% and 10% thresholds) was correlated with the individual bifurcation geometry. Multiple regressions revealed significant (P