The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition.
The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition.
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DOI：
10.2147/ott.s316102
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发表时间：
2021
影响因子：
4
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Du W;Liu X;Yang M;Wang W;Sun J
Prrx1(Pair Related Homeobox 1)是配对同源异型盒家族的成员之一，在肿瘤中发挥重要作用。它与上皮-间充质转化(EMT)的发生密切相关。Prrx1是调节EMT的重要转录因子，在肿瘤进展中起重要作用。在肿瘤转移过程中，Prrx1主要通过转化生长因子-β信号通路、Wnt/β-catenin信号通路和Notch信号通路调控肿瘤细胞内EMT的发生。Prrx1不仅与肿瘤细胞的干性密切相关，而且还参与了对EMT的miRNA调控。因此，Prrx1可能是抑制肿瘤细胞增殖、转移和干细胞分化的靶点。目前的综述提供了Prrx1在癌症上皮-间充质转化过程中的调节作用的系统概述。
PRRX1 (paired related homeobox 1), a member of the paired homeobox family, exhibits an important role in tumor. It is closely correlated to the occurrence of epithelial-mesenchymal transition (EMT). PRRX1 is an important transcription factor regulating EMT and plays an important role in tumor progression. In the process of tumor metastasis, PRRX1 mainly regulates the occurrence of EMT in tumor cells through TGF-β signaling pathway, Wnt/β-catenin signaling pathway and Notch signaling pathway. PRRX1 is not only closely related to the tumor cell stemness but also involved in miRNA regulation of EMT. Therefore, PRRX1 may be a target for inhibiting the proliferation, metastasis and stemness of tumor cells. The current review provides a systemic profile of the regulatory role of PRRX1 in cancer epithelial-mesenchymal transition.