Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus
Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus
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DOI：
10.1016/j.devbrainres.2005.07.002
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发表时间：
2005-10-06
期刊：
影响因子：
--
通讯作者：
Zeisel, SH
中科院分区：
文献类型：
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作者：
Albright, CD;Mar, MH;Zeisel, SH
与对照组相比，妊娠12-17天期间母体膳食胆碱供应的变化导致发育中的胎鼠海马体中免疫活性Netrin-1水平的增加和DCC蛋白水平的下降。发育过程中细胞迁移信号表达的变化可以解释母亲饮食中胆碱供应对认知和记忆过程的一些终生影响。(C)2005 Elsevier B.V.保留所有权利。
Alterations in maternal dietary choline availability during days 12-17 of pregnancy led to an increase in the level of immunoreactive netrin-1 and a decrease in the level of DCC protein in the developing fetal mouse brain hippocampus compared with controls. Changes in the expression of cell migration cues during development could account for some of the lifelong consequences of maternal dietary choline availability for cognitive and memory processes. (c) 2005 Elsevier B.V. All rights reserved.