Cerebral Glucose Metabolism of Parkinson's Disease Patients with Mild Cognitive Impairment
Cerebral Glucose Metabolism of Parkinson's Disease Patients with Mild Cognitive Impairment
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DOI：
10.1159/000315036
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发表时间：
2010-01-01
影响因子：
2.4
通讯作者：
Lee, Myung Sik
中科院分区：
文献类型：
--
作者：
Lyoo, Chul Hyoung;Jeong, Yong;Lee, Myung Sik
背景：一半的帕金森病（PD）患者伴轻度认知障碍（MCI）发展为痴呆。我们研究了不同类型轻度认知损伤PD患者大脑低代谢的地形分布。方法：本研究包括61例非痴呆性PD患者和14例年龄匹配的对照组。PD患者分为正常认知组（PD- nc, n = 20）、单一遗忘组（PD- sa, n = 12）、单一非遗忘组（PD- sn, n = 11）和多域MCI组（PD- md, n = 8）。采用[18F]-氟脱氧葡萄糖PET比较MCI组与对照组和PD-NC组的脑糖代谢。结果：与对照组相比，PD-NC组和PD-SA组未出现低代谢脑区。然而，PD-SN组在顶叶-颞-枕叶皮层表现出代谢低下。PD-MD组表现出广泛的代谢低下，主要累及顶枕皮质。与PD-NC组相比，只有PD-MD组在侧额叶、扣带和顶叶-颞-枕叶皮层表现出代谢低下。结论：PD- md组低代谢脑区分布表明PD- md似乎是由PD痴呆的共同病理引起的。PD-SA和PD-SN似乎是由非常轻微或地形异质性脑功能障碍引起的。需要纵向临床和神经影像学研究来确定单域MCI PD患者是否会发展为PD- md并最终发展为痴呆。版权所有：S. Karger AG，巴塞尔
Background: Half of Parkinson's disease (PD) patients with mild cognitive impairment (MCI) develop dementia. We studied topographic distribution of cerebral hypometabolism in PD with different types of MCI. Methods: This study included 61 nondemented PD patients and 14 age-matched controls. PD patients were grouped into normal cognition (PD-NC, n = 20), single amnestic (PD-SA, n = 12), single nonamnestic (PD-SN, n = 11), and multidomain MCI (PD-MD, n = 8). Using [18F]-fluorodeoxy-glucose PET, cerebral glucose metabolism of MCI groups was compared with that of controls and the PD-NC group. Results: In comparison with controls, PD-NC and PD-SA groups showed no hypometabolic brain areas. However, the PD-SN group showed hypometabolism in parieto-temporo-occipital cortices. The PD-MD group showed widespread hypometabolism that predominantly involved parieto-occipital cortices. In comparison with the PD-NC group, only the PD-MD group showed hypometabolism in lateral frontal, cingulate, and parieto-temporo-occipital cortices. Conclusions: The distribution of hypo-metabolic brain areas of the PD-MD group suggests that PD-MD seems to be caused by a common pathology with PD dementia. PD-SA and PD-SN seem to be caused by very mild or topographically heterogeneous cerebral dysfunction. Longitudinal clinical and neuroimaging studies are needed to define whether PD patients with single domain MCI progress to PD-MD and finally to dementia. Copyright (C) 2010 S. Karger AG, Basel