Stimulation of normal human fibroblast collagen production and processing by transforming growth factor-beta.
Stimulation of normal human fibroblast collagen production and processing by transforming growth factor-beta.
复制标题
通过转化生长因子-β 刺激正常人成纤维细胞胶原蛋白的产生和加工。
DOI：
10.1016/s0006-291x(86)80591-5
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发表时间：
1986
影响因子：
3.1
通讯作者：
Jimenez,SA
中科院分区：
文献类型：
--
作者：
Varga,J;Jimenez,SA
转化生长因子-β (TGF β) 是一种对细胞生长和代谢具有多种影响的生长因子，以剂量依赖性方式显着刺激培养物中汇合的正常人真皮成纤维细胞的总蛋白和胶原蛋白合成。从 TGF β 处理的培养物的培养基中新合成的大分子的凝胶电泳表明原胶原加工加速。这些结果表明TGFβ能够定性和定量地影响成纤维细胞基质分子的生物合成，并提出TGFβ可能在正常和病理性纤维发生的发展中发挥作用的可能性。
Transforming growth factor-β (TGF β) a growth factor with diverse effects on cellular growth and metabolism, caused dramatic stimulation of total protein and collagen synthesis by confluent normal human dermal fibroblasts in culture in a dose-dependent manner. Gel electrophoresis of the newly synthesized macromolecules from the culture media of TGF β treated cultures demonstrated accelerated procollagen processing. These results indicate that TGFβis capable of qualitatively and quantitatively influencing the biosynthesis of matrix molecules by fibroblasts, and raise the possibility that TGF may play a role in the development of normal and pathologic fibrogenesis.