Depressive Symptoms and Change in Abdominal Obesity in Older Persons
Depressive Symptoms and Change in Abdominal Obesity in Older Persons
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DOI：
10.1001/archpsyc.65.12.1386
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发表时间：
2008-12-01
影响因子：
--
通讯作者：
Penninx, Brenda W. J. H.
中科院分区：
文献类型：
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作者：
Vogelzangs, Nicole;Kritchevsky, Stephen B.;Penninx, Brenda W. J. H.
背景：抑郁症被假设为通过内脏脂肪的积累导致腹部肥胖。没有大规模的研究已经测试了这一假说longitudinalized.Objective：为了研究是否抑郁症状预测腹部肥胖的增加在一个大的人口为基础的样本功能良好的老年人。设计：健康，老龄化和身体成分研究，一个正在进行的前瞻性队列研究，随访5年。设置：居住在宾夕法尼亚州匹兹堡和田纳西州孟菲斯周边地区的社区居住老年人。共有2088名功能良好的白色和黑人，年龄在70至79岁之间。主要结果测量：基线抑郁症被定义为流行病学研究中心抑郁评分为16或更高。在基线和5年后，总体肥胖指标包括体重指数（计算方法为体重（千克）除以身高（米）的平方）和体脂百分比（通过双能X射线吸收测定法测量）。腹部肥胖测量包括腰围、矢状径和内脏脂肪结果：在调整社会人口统计学、生活方式、疾病和总体肥胖后，基线抑郁与5年矢状径增加相关（β =.054; P=.01）和内脏脂肪（β = 0.080; P= 0.001）。这项研究表明，抑郁症状会导致腹部肥胖的增加，而与整体肥胖无关，这表明可能存在将抑郁症与内脏脂肪堆积联系起来的特定病理生理机制。这些结果也可能有助于解释为什么抑郁症会增加患糖尿病和心血管疾病的风险。
Context: Depression has been hypothesized to result in abdominal obesity through the accumulation of visceral fat. No large study has tested this hypothesis longitudinally.Objective: To examine whether depressive symptoms predict an increase in abdominal obesity in a large population-based sample of well-functioning older persons.Design: The Health, Aging, and Body Composition Study, an ongoing prospective cohort study with 5 years of follow-up.Setting: Community-dwelling older persons residing in the areas surrounding Pittsburgh, Pennsylvania, and Memphis, Tennessee.Participants: A total of 2088 well-functioning white and black persons aged 70 to 79 years.Main Outcome Measures: Baseline depression was defined as a Center for Epidemiological Studies Depression score of 16 or higher. At baseline and after 5 years, overall obesity measures included body mass index ( calculated as weight in kilograms divided by height in meters squared) and percentage of body fat ( measured by dual-energy x-ray absorptiometry). Abdominal obesity measures included waist circumference, sagittal diameter, and visceral fat ( measured by computed tomography).Results: After adjustment for sociodemographics, lifestyle, diseases, and overall obesity, baseline depression was associated with a 5-year increase in sagittal diameter (beta=.054; P=.01) and visceral fat (beta=.080; P=.001).Conclusions: This study shows that depressive symptoms result in an increase in abdominal obesity independent of overall obesity, suggesting that there may be specific pathophysiological mechanisms that link depression with visceral fat accumulation. These results might also help explain why depression increases the risk of diabetes and cardiovascular disease.