Comparison of serologic responses between Kaposi's sarcoma-positive and -negative men who were seropositive for both human herpesvirus 8 and human immunodeficiency virus
Comparison of serologic responses between Kaposi's sarcoma-positive and -negative men who were seropositive for both human herpesvirus 8 and human immunodeficiency virus
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DOI：
10.1002/jmv.20167
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发表时间：
2004-10-01
影响因子：
12.7
通讯作者：
Luo, W
中科院分区：
文献类型：
--
作者：
Inoue, N;Spira, T;Luo, W
虽然HAART的引入大大降低了卡波西肉瘤（KS）的发病率，但KS仍然是感染人类免疫缺陷病毒（HIV）的个体中最常见的癌症。为了确定从人类疱疹病毒8型（HHV-8）无症状感染进展为KS的标志物，比较了FIN和HHV-8血清阳性的KS阴性和阳性男性之间对HHV-8的血清学应答。两组之间可检测到的中和抗体的患病率没有差异。在双重血清阳性患者中，抗ORF 73抗体的患病率与其KS风险成比例增加。在4-12年期间不同时间间隔从11名HIV+患者获得的标本中，在发生KS的患者中观察到抗ORF 73抗体滴度增加，但在未发生KS的患者中未观察到。这些结果表明，有和没有KS之间的HIV患者对ORF 73的血清学应答存在差异。(C)2004 Wiley-Liss，Inc.
Although the introduction of HAART decreased substantially the incidence of Kaposi's sarcoma (KS), KS remains the most common cancer among individuals infected with human immunodeficiency virus (HIV). To define markers for progression to KS from the asymptomatic infection of human herpesvirus 8 (HHV-8), serologic responses against HHV-8 were compared between KS-negative and -positive men who were seropositive for both FIN and HHV-8. There was no difference in prevalence of detectable neutralizing antibodies between the two groups. The prevalence of anti-ORF73 antibodies among the dual seropositive patients increased in proportion to their risk of KS. In specimens obtained from 11 HIV+ patients at different intervals over a period of 4-12 years, increase of anti-ORF73 antibody titers was observed in the patients who developed KS but not in the patients who did not develop KS. These results suggest that there is a difference in serologic response against ORF73 between the HIV patients with and without KS. (C) 2004 Wiley-Liss, Inc.