Sleep, rhythms, and the endocrine brain: influence of sex and gonadal hormones.
Sleep, rhythms, and the endocrine brain: influence of sex and gonadal hormones.
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DOI：
10.1523/jneurosci.4175-11.2011
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发表时间：
2011-11-09
期刊：
影响因子：
--
通讯作者：
Silver R
中科院分区：
文献类型：
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作者：
Mong JA;Baker FC;Mahoney MM;Paul KN;Schwartz MD;Semba K;Silver R
虽然对睡眠和昼夜节律的机制了解很多，但对性别差异和性腺类固醇对睡眠和生物节律的调节的研究仍处于起步阶段。人们越来越认识到睡眠和节律紊乱方面的性别差异。了解神经内分泌介质和性别差异如何影响睡眠和生物节律，对于促进我们对睡眠相关疾病的理解至关重要。虽然已知卵巢类固醇影响啮齿类动物的昼夜节律，但对雄激素的作用了解较少。令人惊讶的发现，雄激素，通过雄激素受体在主“昼夜节律钟”内的视交叉上核（SCN），调节光对活动的影响，在男性点的昼夜节律控制的新机制。在芳香化酶缺陷（ArKO）小鼠中的研究表明，在发育过程中，光反应的某些性别差异与性腺激素的影响无关。与此同时，据报道，睡眠中的性别差异方面与性腺类固醇无关，并且可能涉及性染色体互补。这是最近工作的总结，说明了性别差异和性腺激素如何影响睡眠和昼夜节律，这是在2011年神经科学学会年会的小型研讨会上提出的。
While much is known about the mechanisms that underlie sleep and circadian rhythms, the investigation into sex differences and gonadal steroid modulation of sleep and biological rhythms is in its infancy. There is a growing recognition of sex disparities in sleep and rhythm disorders. Understanding how neuroendocrine mediators and sex differences influence sleep and biological rhythms is central to advancing our understanding of sleep-related disorders. While it is known that ovarian steroids affect circadian rhythms in rodents, the role of androgen is less understood. Surprising findings that androgens, acting via androgen receptors in the master “circadian clock” within the suprachiasmatic nucleus (SCN), modulate photic effects on activity in males points to novel mechanisms of circadian control. Work in aromatase deficient (ArKO) mice suggests that some sex differences in photic responsiveness are independent of gonadal hormone effects during development. In parallel, aspects of sex differences in sleep are also reported to be independent of gonadal steroids and may involve sex chromosome complement. This a summary of recent work illustrating how sex differences and gonadal hormones influence sleep and circadian rhythms that was presented at a mini-symposium at the 2011 annual meeting of the Society for Neuroscience.