Synaptic Channel Model Including Effects of Spike Width Variation
Synaptic Channel Model Including Effects of Spike Width Variation
复制标题
突触通道模型，包括尖峰宽度变化的影响
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Ö. Akan
中科院分区：
文献类型：
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作者：
H. Ramezani;Ö. Akan
一个精确的神经-棘波通讯模型对于理解分子通讯的基本原理是非常重要的。然而，文献中现有的模型都没有研究轴突传播过程中动作电位形状的变化，轴突传播是神经棘波通信过程中的一个步骤。这些变化会影响通过神经元传递的信息量。因此，分析这些变化的影响，在释放的神经递质，在神经棘波通信的信息载体，是必要的，在推导出一个现实的模型神经棘波通信。在这项工作中，我们改进了现有的通道模型的突触通信涵盖的影响，在海马锥体神经元的动作电位的宽度的变化的基础上，在文献报道的实验数据。假设接收神经元基于Neyman-Pearson方法检测尖峰。我们推导出该检测器的结构，建议的信道模型。数值结果表明，尖峰宽度的增加降低了错误概率。
An accurate model for neuro-spike communication is important in understanding the fundamentals of molecular communication. However, none of the existing models in the literature studied variations in the shape of action potentials during Axonal propagation, one of the steps during neuro-spike communication. These variations affect the amount of information communicated through a neuron. Hence, analyzing effects of these variations in the release of neurotransmitter, the carrier of information in neuro-spike communication, is imperative in deriving a realistic model for neuro-spike communication. In this work, we improve the existing channel models for synaptic communication to cover the effect of changes in the width of action potential on hippocampal pyramidal neurons based on the experimental data reported in the literature. The receiver neuron is assumed to detect spikes based on Neyman-Pearson method. We derive the structure of this detector for the proposed channel model. Numerical results depict that an increase in the spike width decreases the error probability.