The Cognitive Effects of Statins are Modified by Age
The Cognitive Effects of Statins are Modified by Age
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DOI：
10.1038/s41598-020-63035-2
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发表时间：
2020-04-10
影响因子：
4.6
通讯作者：
Schioth, Helgi B.
中科院分区：
文献类型：
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作者：
Alsehli, Ahmed M.;Olivo, Gaia;Schioth, Helgi B.
为了揭示他汀类药物认知效应的新见解，我们对来自英国生物银行的 245,731 名对照者和 55,114 名服用他汀类药物的个体进行了一项基于人群的观察研究。在基线和两次随访（5-10 年内）时对反应时间、工作记忆和流体智力方面的认知表现进行了分析。根据年龄（65岁以下和65岁以上）和治疗持续时间（1-4年、5-10年和10年以上）对受试者进行分类。数据根据健康和认知相关的协变量进行了调整。经过反复评估，受试者的测试成绩普遍有所提高，中年人的表现优于老年人。他汀类药物的使用效果在两个年龄组之间存在显着差异，对老年人的反应时间和两个年龄组的流体智力都有有益的影响，但对年轻受试者的工作记忆有负面影响。我们的分析表明年龄对他汀类药物的认知副作用具有调节作用，揭示了文献中他汀类药物相关认知效应的研究结果极不一致的可能原因。该研究强调了表征他汀类药物效应调节剂的重要性，以提高临床医生在开出他汀类药物处方并评估其对患者副作用时的知识并制定指南。
To reveal new insights into statin cognitive effects, we performed an observational study on a population-based sample of 245,731 control and 55,114 statin-taking individuals from the UK Biobank. Cognitive performance in terms of reaction time, working memory and fluid intelligence was analysed at baseline and two follow-ups (within 5-10 years). Subjects were classified depending on age (up to 65 and over 65 years) and treatment duration (1-4 years, 5-10 years and over 10 years). Data were adjusted for health- and cognition-related covariates. Subjects generally improved in test performance with repeated assessment and middle-aged persons performed better than older persons. The effect of statin use differed considerably between the two age groups, with a beneficial effect on reaction time in older persons and fluid intelligence in both age groups, and a negative effect on working memory in younger subjects. Our analysis suggests a modulatory impact of age on the cognitive side effects of statins, revealing a possible reason for profoundly inconsistent findings on statin-related cognitive effects in the literature. The study highlights the importance of characterising modifiers of statin effects to improve knowledge and shape guidelines for clinicians when prescribing statins and evaluating their side effects in patients.