ONTOGENY OF CONTEXTUAL FEAR CONDITIONING IN RATS - IMPLICATIONS FOR CONSOLIDATION, INFANTILE AMNESIA, AND HIPPOCAMPAL SYSTEM FUNCTION
ONTOGENY OF CONTEXTUAL FEAR CONDITIONING IN RATS - IMPLICATIONS FOR CONSOLIDATION, INFANTILE AMNESIA, AND HIPPOCAMPAL SYSTEM FUNCTION
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DOI：
10.1037/0735-7044.108.2.227
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发表时间：
1994-04-01
影响因子：
1.9
通讯作者：
MORLEDGE, P
中科院分区：
文献类型：
--
作者：
RUDY, JW;MORLEDGE, P
作者提出的发展证据表明，上下文恐惧条件反射是由短期记忆系统支持的，支持条件反射后立即休克和长期记忆系统，支持上下文条件反射训练后24小时。这是基于这样的发现，即在1次条件反射试验后，18 - 32日龄大鼠在条件反射后立即测试时显示出相同量的条件反射冻结，但18日龄大鼠在保留间隔为24小时时显示出比老年大鼠少得多的条件反射冻结。数据还表明，长时间的条件反射冻结对大鼠的行为有影响。直到条件反射试验后几个小时才能获得介导条件性恐惧的上下文术语记忆表征。这些研究结果的影响记忆巩固过程，婴儿健忘症，海马结构的发展进行了讨论。
The authors present developmental evidence that contextual fear conditioning is supported by a short-term memory system that supports conditioning immediately after a shock and by a long-term memory system that supports contextual conditioning 24 hr after training. This is based on the finding that after 1 conditioning trial, rats 18 to 32 days old show the same amount of conditioned freezing when tested immediately after conditioning but 18-day-old rats show much less conditioned freezing than the older rats when the retention interval is 24 hr. The data also suggest that the long-term memory representation df context that mediates conditioned fear is not available until several hours after the conditioning trial. Implications of these findings for memory consolidation processes, infantile amnesia, and hippocampal formation development are discussed.