Environmental enrichment lowers stress-responsive hormones in singly housed male and female rats
Environmental enrichment lowers stress-responsive hormones in singly housed male and female rats
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DOI：
10.1016/j.pbb.2003.09.005
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发表时间：
2003-12-01
影响因子：
3.6
通讯作者：
Rhodes, ME
中科院分区：
文献类型：
--
作者：
Belz, EE;Kennell, JS;Rhodes, ME
环境系统的结构和社会方面可以影响占据该系统的动物的生理和行为。本研究检测了在基础和轻度应激条件下，环境富集（EE）与Kong（R）Toys（R）和Nestlets（R）对下丘脑-垂体-肾上腺（HPA）轴应激反应激素的生理效应。雄性和雌性大鼠。与EE一起饲养的两种性别的动物具有显著较低的基线促肾上腺皮质激素（ACTH）和皮质酮（CORT）浓度相比，那些没有EE。ACTH反应的生理盐水注射的轻度应激显着降低与EE圈养的雌性大鼠。与香港玩具和雀巢的相互作用似乎提供了从单调的笼生活的大鼠转移，导致较低的HPA轴活动之前和之后的轻度应激。这些结果是重要的，因为低，稳定的基线是必不可少的准确辨别药理学和其他影响HPA轴。(C)2003年爱思唯尔公司All rights reserved.
Structural and social aspects of an environmental system can influence the physiology and behavior of animals occupying that system. This study examined the physiological effects of environmental enrichment (EE) with Kong(R) Toys(R) and Nestlets(R) on stress-responsive hormones of the hypothalamic-pituitary-adrenal (HPA) axis under basal and mild stress conditions in singly housed, jugular vein-cannulated, male and female rats.Animals of both sexes housed with EE had significantly lower baseline adrenocorticotropic hormone (ACTH) and corticosterone (CORT) concentrations compared to those housed without EE. ACTH responses to the mild stress of saline injection were significantly lower in female rats housed with EE.Interaction with the Kong Toys and Nestlets appears to have provided the rats with a diversion from monotonous cage life, resulting in lower HPA axis activity before and after mild stress. These results are important because low, stable baselines are essential for accurately discerning pharmacological and other influences on the HPA axis. (C) 2003 Elsevier Inc. All rights reserved.