DELAY-RELATED ACTIVITY OF PREFRONTAL NEURONS IN RHESUS-MONKEYS PERFORMING DELAYED-RESPONSE
DELAY-RELATED ACTIVITY OF PREFRONTAL NEURONS IN RHESUS-MONKEYS PERFORMING DELAYED-RESPONSE
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DOI：
10.1016/0006-8993(82)91145-3
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发表时间：
1982-01-01
期刊：
影响因子：
2.9
通讯作者：
GOLDMANRAKIC, PS
中科院分区：
文献类型：
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作者：
KOJIMA, S;GOLDMANRAKIC, PS
在提示和反应之间分别间隔2、4、8或12秒的空间延迟反应任务中，研究了恒河猴背外侧前额叶皮层神经元的活动。在每种延迟条件下至少10次试验记录的600个神经元中，有95个神经元在延迟期间表现出放电模式，与此之前或之后的神经元放电模式明显不同。延迟持续时间的变化在这些神经元中引发了两种不同的活动模式：一些（59/ 95,62%）表现出固定的放电模式，而不管随后的延迟持续时间；其他的（31/ 95,33 %）则改变了与时间变化相关的活动模式。尽管这两种类型的延迟相关神经元都表现出不同的放电特征，但每一类中超过一半的神经元在延迟期的早期表现出最高的活动。一个相关的发现涉及到一小部分空间选择性神经元，当提示出现在左侧时，它们的反应明显比出现在右侧时要强烈，反之亦然。惊人的是，80%的这些空间辨别神经元在延迟期的最初几秒钟内表现出峰值活动。这些发现提供了细胞证据：(1)前额叶神经元对延迟反应任务的时间和空间特征都有反应；(2)在延迟的最初几秒钟，这些子集的参与尤为关键。后者的发现强调了前额叶神经元可能在空间记忆的配准过程中发挥重要作用。
Activity of dorsolateral prefrontal cortical neurons was examined in rhesus monkeys while they performed a spatial delayed-response task with delays of 2, 4, 8 or 12 s interposed between cue and response. Of the 600 neurons recorded for at least 10 trials under each delay condition, 95 displayed a pattern of discharge during the delay period which was significantly different from neuronal firing before or after this period. Changes in the duration of the delay elicit two distinct patterns of activity in these neurons: some (59/95, 62%) exhibit a fixed pattern of discharge regardless of the duration of the ensuing delay; others (31/95, 33%) alter their pattern of activity in relation to the temporal changes. Although both types of delay-related neurons display a variety of discharge profiles, more than half of each class exhibit their highest activity in the early part of the delay period. A related finding concerns a small subclass of spatially selective neurons which fire significantly more when the cue is presented on the left than on the right or vice versa. A striking 80% of these spatially discriminative neurons exhibit peak activity in the first few seconds of the delay period. These findings provide cellular evidence that (1) prefrontal neurons are responsive to temporal as well as spatial features of the delayed-response task; and (2) the involvement of a subset of these is particularly critical in the first few seconds of the delay. The latter finding emphasizes that prefrontal neurons may play an important role in the registration process of spatial memory.