Intranasal trigeminal chemosensitivity in patients with postviral and post-traumatic olfactory dysfunction
Intranasal trigeminal chemosensitivity in patients with postviral and post-traumatic olfactory dysfunction
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DOI：
10.3109/00016489.2012.663933
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发表时间：
2012-08
影响因子：
1.4
通讯作者：
Yuan-yuan Ren;Ling Yang;Yichen Guo;Miao Xutao;Kun-yan Li;Yongxiang Wei
中科院分区：
文献类型：
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作者：
Yuan-yuan Ren;Ling Yang;Yichen Guo;Miao Xutao;Kun-yan Li;Yongxiang Wei
摘要结论：嗅神经和鼻内三叉神经系统联系密切。嗅觉功能障碍(OD)患者三叉神经事件相关电位(ERP)潜伏期延长，波幅降低，提示三叉神经敏感性降低。不同的年龄、病因和嗅觉状况对三叉神经敏感度的影响也不同。目的：强迫症是鼻科临床常见症状。事件相关电位被认为是评价药物敏感性的重要方法。本研究的目的是探讨病毒后OD(PVOD)和创伤后OD(PTOD)患者鼻内三叉神经感觉的变化。方法：对96名20~65岁的健康成人和66名OD患者进行问卷调查。采用T&T嗅觉仪、Sniffin‘Sniffin棒嗅觉试验和三叉神经诱发电位(Terps)。我们评估了不同因素(年龄、病因和嗅觉状态)对嗅觉功能正常的健康受试者以及PVOD和PTOD患者三叉神经敏感度的影响。结果：OD患者的三叉神经阈值高于正常对照组。与对照组相比，OD患者的TERP的N1/P2潜伏期延长，波幅降低。在对照组和OD组，年龄较大的受试者表现出比年轻受试者更长的潜伏期和更低的波幅。PTOD患者的心理物理嗅觉功能较差，三叉神经敏感度降低。
Abstract Conclusions: The olfactory and intranasal trigeminal systems are closely connected. With regard to intranasal trigeminal event-related potential (ERP), patients with olfactory dysfunction (OD) showed longer latency and lower amplitude, which indicated decreased trigeminal sensitivity. Different age, etiology, and olfactory status also affect trigeminal sensitivity differently. Objective: OD is a common symptom in the rhinology clinic. ERP is considered an important method to evaluate chemosensitivity. The aim of this study was to investigate changes of intranasal trigeminal sense in patients with postviral OD (PVOD) and post-traumatic OD (PTOD). Methods: A total of 96 participants (30 healthy adults and 66 patients with OD) aged 20–65 years were investigated. The T&T olfactometer, the Sniffin' Sticks olfactory test, and trigeminal ERPs (tERPs) were used. We evaluated trigeminal sensitivity influenced by different factors (age, etiology, and olfactory status) in healthy subjects with normal olfactory function and in patients with PVOD and PTOD. Results: Patients with OD showed higher trigeminal thresholds than normal controls. Compared with controls, N1/P2 latencies of tERPs increased and amplitudes decreased in patients with OD. Older subjects showed longer latencies and lower amplitudes than young subjects in both controls and the OD group. Patients with PTOD exhibited worse psychophysical olfactory function and decreased trigeminal sensitivity.