High‐density lipoprotein affects antigen presentation by interfering with lipid raft: a promising anti‐atherogenic strategy
High‐density lipoprotein affects antigen presentation by interfering with lipid raft: a promising anti‐atherogenic strategy
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DOI：
10.1111/j.1365-2249.2009.04068.x
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发表时间：
2010-05
影响因子：
4.6
通讯作者：
S-H Wang;S.-G. Yuan;D. Peng;S. Zhao
中科院分区：
文献类型：
--
作者：
S-H Wang;S.-G. Yuan;D. Peng;S. Zhao
动脉粥样硬化是一种慢性炎症性疾病。动脉粥样硬化的免疫调节成为预防和治疗这种广泛流行疾病的一种有前途的方法。高密度脂蛋白（HDL）促进胆固醇逆向转运的功能可以解释其对动脉粥样硬化的保护能力。HDL和载脂蛋白A-I（apoA-I）抑制抗原呈递细胞（APC）刺激T细胞的能力的发现可能归因于脂筏，一种富含胆固醇的微结构域，其功能特性主要取决于其脂质组成。因此，调节脂筏中的胆固醇可能提供有希望的抗动脉粥样硬化策略。
Atherosclerosis is a chronic inflammatory disease. Immunomodulation of atherosclerosis emerges as a promising approach to prevention and treatment of this widely prevalent disease. The function of high‐density lipoprotein (HDL) to promote reverse cholesterol transport may explain the ability of its protection against atherosclerosis. Findings that HDL and apolipoprotein A‐I (apoA‐I) inhibited the ability of antigen presenting cells (APCs) to stimulate T cells might be attributed to lipid raft, a cholesterol‐rich microdomain exhibiting functional properties depending largely upon its lipid composition. Thus, modulating cholesterol in lipid raft may provide a promising anti‐atherogenic strategy.