Modulation of blood pressure by substance P: opposite effects of N- and C- terminal fragments on anesthetized rats.
Modulation of blood pressure by substance P: opposite effects of N- and C- terminal fragments on anesthetized rats.
复制标题
P 物质调节血压：N 端和 C 端片段对麻醉大鼠的相反作用。
DOI：
10.1016/0024-3205(87)90050-6
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发表时间：
1987
期刊：
影响因子：
6.1
通讯作者：
Stewart,JM
中科院分区：
文献类型：
--
作者：
Hall,ME;Miley,FB;Stewart,JM
大量证据表明，P物质（SP）可能是一种介导脑干内压力感受器反射激活的降压作用的递质，但据报道，脑室内给药SP会产生明显的降压作用。在本研究中，SP注入第4脑室产生双相效应；血压短暂下降后又长时间升高。同样注射SP的羧基端片段只产生长时间的升压作用。注射氨基端SP片段仅产生短暂、快速的抑制作用。这些结果提示SP的氨基末端序列可能参与调节压力感受器激活的抑制作用。
Considerable evidence suggests that substance P (SP) may be a transmitter mediating the depressor effects of baroreceptor reflex activation within the brainstem, yet intracerebroventicular administration of SP is reported to result in a pronounced pressor effect. In this study, SP injected into the 4th cerebral ventricle produced a biphasic effect; a brief decrease in blood pressure followed by a lengthy increase. Similar injections of a carboxyterminal fragment of SP produced only a pressor effect of long duration. Injection of an amino-terminal SP fragment produced only a brief, rapid depressor effect. These results suggest that the amino-terminal sequence of SP may be involved in mediating the depressor effects of baroreceptor activation.