Inhibition of gamma-glutamyl transpeptidase and induction of glutathionuria by gamma-glutamyl amino acids.
Inhibition of gamma-glutamyl transpeptidase and induction of glutathionuria by gamma-glutamyl amino acids.
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γ-谷氨酰氨基酸抑制γ-谷氨酰转肽酶并诱导谷胱甘肽尿。
DOI：
10.1073/pnas.83.14.5029
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发表时间：
1986
影响因子：
11.1
通讯作者：
A. Meister
中科院分区：
文献类型：
--
作者：
M. Anderson;A. Meister
用各种γ-谷氨酰氨基酸处理小鼠导致谷胱甘肽和其他γ-谷氨酰化合物的显著尿排泄。γ-谷氨酰转肽酶对各种γ-谷氨酰氨基酸的亲和力与谷胱甘肽尿症的程度之间有很好的相关性。研究结果表明，给予的γ-谷氨酰化合物有效地与谷胱甘肽（从肾细胞输出并存在于肾小球滤液中）竞争酶。某些γ-谷氨酰氨基酸的给药似乎是体内抑制γ-谷氨酰转肽酶的特异性和无毒程序，可用于谷胱甘肽代谢和功能的实验工作，也可用于治疗某些毒性和调节内源性谷胱甘肽结合物的代谢。
Treatment of mice with various gamma-glutamyl amino acids leads to marked urinary excretion of glutathione and other gamma-glutamyl compounds. There is good correlation between the affinity of gamma-glutamyl transpeptidase for various gamma-glutamyl amino acids and the extent of glutathionuria. The findings indicate that the administered gamma-glutamyl compounds effectively compete with glutathione (exported from kidney cells and present in the glomerular filtrate) for the enzyme. The administration of certain gamma-glutamyl amino acids appears to be a specific and nontoxic procedure for in vivo inhibition of gamma-glutamyl transpeptidase that may be useful in experimental work on glutathione metabolism and function and also for treatment of certain toxicities and for modulation of the metabolism of endogenous glutathione conjugates.